| 王夏云,陈 民,全守霞,赵 宁,李 雪.稳心颗粒对急性心肌梗死患者心率变异性及血清炎症因子水平的影响[J].现代生物医学进展英文版,2017,17(12):2282-2285. |
| 稳心颗粒对急性心肌梗死患者心率变异性及血清炎症因子水平的影响 |
| Effects of Wenxin Granules on Heart Rate Variability and Serum Levels of Inflammatory Factors in Patients with Acute Myocardial Infarction |
| Received:November 12, 2016 Revised:December 03, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.12.020 |
| 中文关键词: 心律失常 稳心颗粒 急性心肌梗死 炎症因子 心率变异性 |
| 英文关键词: Arrhythmia Wenxin granules Acute myocardial infarction Inflammatory factors Heart rate variability |
| 基金项目:辽宁省科技厅计划项目(2013226012） |
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| 中文摘要: |
| 摘要 目的：探讨稳心颗粒治疗急性心肌梗死性心律失常的疗效及对患者血清炎症因子水平的影响。方法：选择2013年6月-2016年6月在我院接受治疗的168例急性心肌梗死患者为研究对象，随机分为研究组和对照组，每组84例。对照组患者给予常规西药治疗，研究组患者在对照组基础上给予稳心颗粒口服治疗。观察并比较两组患者治疗前后心率变异性、每搏输出量（SV）、左心室射血分数（LVEF）、左心室舒张末径（LVEDD）、血清IL-6水平以及临床疗效。结果：与治疗前比较，两组患者治疗后SDNN，SDNN Index，SDANN，HF及LF均升高，而LF/HF值均降低，差异具有统计学意义（P<0.05）；与对照组比较，研究组患者治疗后SDNN，SDNN Index，SDANN，HF及LF较高，而LF/HF值较低，差异具有统计学意义（P<0.05）。与治疗前比较，两组患者治疗后LVEF及SV均升高，而LVEDD均降低，差异具有统计学意义（P<0.05）；与对照组比较，研究组患者治疗后LVEF及SV较高，而LVEDD较低，差异具有统计学意义（P<0.05）。与治疗前比较，两组患者治疗后血清IL-6水平均降低，差异具有统计学意义（P<0.05）；与对照组比较，研究组患者治疗后血清IL-6水平较低，差异具有统计学意义（P<0.05）。研究组临床总有效率（91.7%）显著高于对照组（82.1%），差异具有统计学意义（P<0.05）。结论：稳心颗粒治疗急性心肌梗死的临床疗效显著，不仅能够改善患者心律失常症状，还能降低血清炎症因子水平，值得临床进一步推广及应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of Wenxin granules on the treatment of acute myocardial infarction and its effects on the serum levels of inflammatory factors of patients. Methods: 168 patients with acute myocardial infarction who were treated in our hospital from June 2013 to June 2016 were selected and randomly divided into the study group and the control group, with 84 cases in each group. The patients in the control group were treated with conventional methods, while the patients in the study group were treated with Wenxin granules on the basis of the control group. Then the heart rate variability, stroke volume (SV), left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), and serum levels of IL-6 of the two groups were observed and compared before and after the treatment. Results: Compared with before treatment, the SDNN, SDNN index, SDANN, HF and LF of the two groups increased after the treatment, while the LF/HF decreased, and the differences were statistically significant (P<0.05); Compared with the control group after the treatment, the SDNN, SDNN index, SDANN, HF and LF of the study group were higher, while the LF/HF was lower, and the differences were statistically significant (P<0.05); Compared with before treatment, the LVEF and SV of the two groups increased after the treatment, while the LVEDV decreased, and the differences were statistically significant (P<0.05); Compared with the control group after the treatment, the LVEF and SV of the study group were higher, while the LVEDV was lower, and the differences were statistically significant (P<0.05); Compared with before treatment, the serum levels of IL-6 of the two groups decreased after the treatment, and the difference was statistically significant (P<0.05); Compared with the control group after the treatment, the serum levels of IL-6 was lower in the study group, and the difference was statistically significant (P<0.05). The total effective rate of the study group was 91.7%, which was significantly higher than 82.1% of the control group, and the difference was statistically significant (P<0.05). Conclusion: Wenxin granules has obvious clinical effect on the treatment of acute myocardial infarction, which can improve the symptoms of arrhythmia, as well as reduce the serum levels of inflammatory factors, and it is worthy of further clinical application. |
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