| 阿迪力江·喀日,阿曼姑·阿不都沙拉木,郭艳芳,朱洪涛,阿布来提·阿布都卡德尔.肝细胞生长因子和基质金属蛋白酶-9在过敏性紫癜中表达的意义[J].现代生物医学进展英文版,2017,17(12):2279-2281. |
| 肝细胞生长因子和基质金属蛋白酶-9在过敏性紫癜中表达的意义 |
| Expressions of Hepatocyte Growth Factor and Matrix Metalloproteinases -9 in Henoch-Schonlein Purpura |
| Received:July 30, 2016 Revised:August 23, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.12.019 |
| 中文关键词: 过敏性紫癜/过敏性紫癜肾炎 肝细胞生长因子 基质金属蛋白酶-9 尿蛋白定量 |
| 英文关键词: Henoch-schonlein purpura/Henoch-schonlein purpura nephritis Hepatocyte growth factor Matrix metalloproteinases -9 Urine protein quantitative |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2014211C097） |
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| 中文摘要: |
| 摘要 目的：探讨肝细胞生长因子（HGF）和基质金属蛋白酶-9（MMP-9）在儿童过敏性紫癜（HSP）中表达的意义，探寻肾脏损害预测的敏感指标。方法：选取HSP与过敏性紫癜肾炎（HSPN）患儿各30例，并选取同期体检的健康儿童30名作为对照组，采用酶联免疫吸附试验法（ELISA）检测3组血清和尿液中的HGF及血清MMP-9含量，并采用比浊法检测24 h尿蛋白，分析HGF、MMP-9与24 h尿蛋白的相关性。结果：HSP组、HSPN组血清、尿液HGF，血清MMP-9及尿蛋白定量均高于对照组（P＜0.05）；HSPN组中Ⅱ~Ⅳ期患者血清HGF及Ⅰ~Ⅳ期尿液HGF、Ⅲ~Ⅳ期MMP-9及Ⅰ~Ⅳ期尿蛋白定量均高于HSP组（P＜0.05）；血清及尿液HGF与血清MMP-9无明显相关性（r＝0.014，0.027，P＞0.05）；血清HGF与尿蛋白定量无明显相关性（r＝0.032，P＞0.05）；尿液HGF、血清MMP-9与尿蛋白定量均呈正相关（r＝0.412、0.302，P＜0.05）。结论：尿液HGF、MMP-9均参与HSP、HSPN病情的发展，尿液HGF、MMP-9水平的监测有助于评估HSPN的病情及预后，但HGF与MMP-9之间无明显相关性。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate expressions of hepatocyte growth factor (HGF) and matrix metalloproteinases-9 (MMP-9) in henoch-schonlein purpura (HSP), and to explore the sensitive indicators of nephritis. Methods: 30 children with henoch schonlein purpura nephritis (HSPN) were selected as the (HSPN group, and another 30 healthy children were selected as the control group. The enzyme-linked immunosorbent assay (ELISA) was applied to detect the HGF levels in serum and urine and serum contents of MMP-9, and turbidimetric method was used to detect the 24 h urine protein. Analyze the correlation of MMP-9 and HGF with 24 h urine protein. Results: The levels of urine and serum HGF, serum MMP-9 and urinary protein were higher in HSP and HSPN group than in control group (P<0.05). The levels of serum HGF of Ⅱ ~ Ⅳ stage patients, the urine levels of HGF of Ⅰ~ Ⅳ stage patients, the serum levels of MMP-9 of Ⅲ~ Ⅳ stage patients and the urinary protein levels of Ⅰ~ Ⅳ stage patients were higher in HSPN group than in HSP group (P<0.05). Serum and urine HGF levels had no significant correlation with MMP-9 serum levels (r=0.014, 0.027, P>0.05). Serum HGF had no significant correlation with urine protein quantitative (r=0.032, P>0.032). HGF urine level and MMP-9 serum level both had a positive correlation with urine protein quantitative (r=0.412, 0.302, P<0.05). Conclusion: The urine HGF and MMP-9 participates in the development of HSP and HSPN. The monitoring on the levels of urine HGF and MMP-9 may help to assess the state and prognosis of HSPN. But there was no significant correlation between HGF and MMP-9. |
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