| 周思欣,卢灿荣,彭 正,李 晨,宋 舟,陈 凛.胃癌患者围术期血清TNF-α, NO及IGF-Ⅱ水平变化及意义[J].现代生物医学进展英文版,2017,17(12):2264-2266. |
| 胃癌患者围术期血清TNF-α, NO及IGF-Ⅱ水平变化及意义 |
| Expression of Perioperative Serum TNF-α, NO, IGF-Ⅱ in Patients with Gastric Cancer and its Significance |
| Received:October 17, 2016 Revised:November 11, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.12.015 |
| 中文关键词: 胃癌 围手术期 肿瘤坏死因子-α 一氧化氮 胰岛素样生长因子-II |
| 英文关键词: Gastric cancer Perioperative Tumor necrosis factor-α Nitric oxide Insulin-like growth factor II |
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| 中文摘要: |
| 摘要 目的：探讨胃癌患者围手术期血清肿瘤坏死因子-α（TNF-α）、一氧化氮（NO）及胰岛素样生长因子-II（IGF-II）水平的变化及其临床意义。方法：收集2014年8月至2016年8月于我院收治的117例行胃癌根治术的胃癌患者（病例组），随机选取的60例健康体检者（对照组）为研究对象，采用酶联免疫测定法（ELISA）测定两组的血清TNF-α水平，硝酸还原法测定NO水平，双抗体放射免疫法测定IGF-II水平。结果：病例组患者术前血清TNF-α、IGF-II水平均高于对照组，NO水平低于对照组，差异有统计学意义（P<0.05）。病例组术后3 d、7 d、10 d血清TNF-α、IGF-II水平均呈逐渐下降趋势，且均低于术前，差异有统计学意义（P<0.05），术后10d血清TNF-α、IGF-II水平与对照组比较无差异（P>0.05）；而血清NO水平在术后3 d、7 d、10 d均呈逐渐上升趋势，且均高于术前，差异有统计学意义（P<0.05），术后10d血清NO水平与对照组比较无差异（P>0.05）。经Pearson积矩相关分析，术前病例组患者TNF-α、IGF-II之间呈正相关关系（r=0.733，P<0.05），TNF-α、IGF-II与NO之间均呈负相关关系（r=-0.681、-0.716，P<0.05）。结论：胃癌患者术前血清TNF-α、IGF-Ⅱ呈高表达，NO呈低表达，术后随着时间的延长，TNF-α、IGF-Ⅱ、NO逐渐趋于正常，联合检测围手术期血清TNF-α、NO、IGF-Ⅱ有助于早期评估胃癌病情及判断预后。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the expression of perioperative serum tumor necrosis factor-alpha (TNF-α),nitric oxide(NO),insulin-like growth factor II(IGF-Ⅱ)in patients with gastric cancer and its clinical significance. Methods: 117 patients with gastric cancer underwent radical gastrectomy (case group) and 60 healthy volunteers (control group) selected randomly in our hospital from August 2014 to August 2016 were collected. The TNF-α level of two groups was detected by the enzyme-linked immunosorbent assay(ELISA),the NO levels was detected by the nitrate reduction, the IGF-II level was detected by the double-antibody radioimmunoassay. Results: The serum TNF-α, IGF-II levels of case group before operation were higher than those of control group, and the NO level was lower than that of control group, the differences were statistically significant(P<0.05). The serum TNF-α, IGF-II levels showed a declining trend at 3 d, 7 d, 10 d after operation, and which were lower than those before operation, the difference was statistically significant(P<0.05). Compared with the control group, the serum levels of TNF-α, IGF-II at 10 d after operation were not different (P>0.05). And serum NO levels at 3 d, 7 d, 10 d after operation were gradually increased, which were higher than that before operation, the difference was statistically significant(P<0.05), there was no difference in serum NO level between the control group and 10d after operation(P>0.05). By the Pearson product-moment correlation analysis, a positive association between TNF-α and IGF-II before operation was found(r=0.733, P<0.05). There was a negative relationship between NO and TNF-α, IGF-II.(r=-0.681, -0.716, P<0.05). Conclusion: The serum TNF-α, IGF-II preoperative in patients with gastric cancer show high expression, and low expression of NO, with the extension of time,TNF-α, IGF- II, NO gradually became normal. Combined detection of serum TNF-α, NO and IGF- in the perioperative period is helpful to evaluate the prognosis of gastric cancer. |
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