| 武春银,疏树华,柴小青,谢言虎,李传耀,章 敏.盐酸羟考酮注射液用于腹部全麻患者术后镇痛的有效性和安全性[J].现代生物医学进展英文版,2017,17(11):2131-2133. |
| 盐酸羟考酮注射液用于腹部全麻患者术后镇痛的有效性和安全性 |
| Efficacy and Safety of Oxycodone Hydrochloride Injection for Postoperative Analgesia in Patients Undergoing Operation under General Anesthesia |
| Received:December 07, 2016 Revised:December 26, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.11.034 |
| 中文关键词: 腹部手术 术后镇痛 盐酸羟考酮 硫酸吗啡 |
| 英文关键词: Abdominal surgery Postoperative anesthesia Oxycodone hydrochloride Morphine sulfate |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨盐酸羟考酮注射液用于腹部全麻患者术后镇痛的有效性和安全性。方法：选择2016年1月至2016年12月来我院治疗的择期全麻下行腹部手术的患者60例。按照治疗方法，采用随机数字表法将患者平均分为硫酸吗啡注射组(简称吗啡组)和盐酸羟考酮注射组(简称羟考酮组)，每组30例。用药3、24、48 h后，采用VAS方法对患者进行疼痛评分。记录术后48 h内患者补救镇痛率以及患者对镇痛的满意度。记录72 h后患者恶心、呕吐等不良事件的发生情况。结果：镇痛48 h内的不同时间点，两组间VAS评分、补救镇痛率与吗啡组相比无显著差异(P>0.05)。羟考酮组术后不良事件发生率为16.7 %，显著低于吗啡组40.0 %(P<0.05)，羟考酮组患者镇痛满意度显著高与吗啡组(93.3 % vs. 70.0 %)，差异具有统计学意义(P<0.05)。结论：盐酸羟考酮注射液的镇痛效果与硫酸吗啡相当，且可安全有效地改善患者术后生活质量，提高患者满意度。 |
| 英文摘要: |
| ABSTRACT Objective: To study the efficacy and safety of oxycodone hydrochloride injection for postoperative analgesia in pa- tients undergoing operation under general anesthesia. Methods: Sixty patients undergoing operation under general anesthesia admitted in- to our hospital from Jan 2016 to Dec 2016 were randomly divided into oxycodone group (n=30) and morphine group (n=30). According to the group, the patients were received oxycodone or morphine. Pain was assessed using VAS score at 3 h, 24 h and 48 h after adminis- tration. Requirement for rescue analgesic and the level of Patients' satisfaction were recorded within 48 h after operation. The adverse events were recorded within 72 h after administration. Results: There was no significant difference in the VAS scores and requirement for rescue analgesic(P>0.05). The adverse events in oxycodone group were obviously fewer than that of morphine group (16.7 % vs. 40.0 %, P<0.05). The level of patient's satisfaction in oxycodone group were obviously higher than that of morphine group (93.3 % vs. 70.0 %, P<0.05). Conclusion: The analgesic efficacy of oxycodone is similar to that of morphine, and oxycodone can effectively reduce postoper- ative pain, improve the quality of life of patients after surgery and improve patient satisfaction. |
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