| 王 亮,田 洁,许跃军,田 伟,刘明凯.后腹腔镜根治术对肾癌患者免疫功能的影响[J].现代生物医学进展英文版,2017,17(11):2110-2112. |
| 后腹腔镜根治术对肾癌患者免疫功能的影响 |
| Effect of Retroperitoneal Laparoscopic Radical Nephrectomy on Immune Functions of Patients with Renal Cell Carcinoma |
| Received:October 12, 2016 Revised:October 29, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.11.028 |
| 中文关键词: 肾癌 后腹腔镜根治术 传统开放手术 免疫功能 |
| 英文关键词: Renal cell carcinoma Retroperitoneal laparoscopic radical nephrectomy Conventional open surgery Immune function |
| 基金项目:河北省科技攻关项目(0276136Z） |
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| 中文摘要: |
| 摘要 目的：探讨后腹腔镜肾癌根治术对患者免疫功能的影响。方法：选择2013年5月-2015年5月在我院接受手术治疗的肾癌患者67例，根据手术方法不同分为研究组（37例）及对照组（30例）。研究组患者采用后腹腔镜肾癌根治术治疗，对照组患者采用传统开放手术治疗。观察并比较两组患者的手术时间、术中出血量、住院时间以及手术前后患者外周血T淋巴细胞亚群的变化情况。结果：研究组患者的手术时间、术中出血量及住院时间均少于对照组，差异具有统计学意义（P＜0.05）。两组患者术前外周血T淋巴细胞CD3+、CD4+、CD8+及CD4+/CD8+比较，差异无统计学意义（P>0.05）；两组患者术后外周血T淋巴细胞CD3+、CD4+及CD4+/CD8+明显降低，但研究组高于对照组，差异具有统计学意义（P<0.05）；两组患者术后CD8+比较，差异无统计学意义（P>0.05）。结论：与传统开放手术相比较，后腹腔镜肾癌根治术对患者免疫功能的影响较小，手术时间短，术中出血量少，临床疗效显著，值得推广及应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of retroperitoneal laparoscopic radical nephrectomy on the immune function of patients with renal cell carcinoma. Methods: 67 cases with renal carcinoma who were treated in our hospital from May 2013 to May 2015 were selected and according to the different operation methods, the patients were divided into the study group (37 cases) and the control group (30 cases). The patients in the study group were treated with retroperitoneal laparoscopic radical nephrectomy, and the patients in the control group were treated with conventional open surgery. Then the duration of the operation, the amount of blood loss, the hospitalization and the changes of T lymphocyte subsets in the peripheral blood of patients were observed and compared between the two groups before and after operation. Results: The duration of the operation, the amount of blood loss and hospitalization of patients in the study group were less than those of the control group, and the differences were statistically significant (P<0.05); There was no statistically significant difference about the levels of CD3+, CD4+, CD8+ and CD4+/CD8+ in the peripheral blood of patients between the two groups before surgery (P>0.05); The levels of CD3+, CD4+ and CD4+/CD8+ in the peripheral blood of patients in the two groups decreased after the operation, while the study group was higher than that of the control group, and the differences were statistically significant (P<0.05); There was no statistically significant difference about CD8+ in the peripheral blood of patients between the two groups after the operation (P>0.05). Conclusion: Compared with the conventional open surgery, the retroperitoneal laparoscopic radical nephrectomy has less influence on the immune functions of patients with renal cell carcinoma, with shorter operation time, less blood loss, and better clinical curative effect, which is worthy of clinical application. |
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