| 付大鹏,覃开蓉,廉皓屹,杨 圣,芦健民,赵德伟.骨保护素对激素性股骨头坏死患者功能恢复及血清TRAP和CTX-Ⅱ水平的影响[J].现代生物医学进展英文版,2017,17(11):2064-2067. |
| 骨保护素对激素性股骨头坏死患者功能恢复及血清TRAP和CTX-Ⅱ水平的影响 |
| Effect of Bone Protective Hormone on the Functional Recovery and the Level of Serum TRAP and CTX-Ⅱ of Patients with Steroid Induced Avascular Necrosis of the Femoral Head |
| Received:October 17, 2016 Revised:November 10, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.11.016 |
| 中文关键词: 骨保护素 激素性股骨头坏死 髋关节功能 抗酒石酸酸性磷酸酶 Ⅱ型胶原羧基端端肽 |
| 英文关键词: Bone protection element Steroid induced necrosis of the femoral head Hip joint function Tartrate resistant acid phosphatase C-telopeptide fragments of type Ⅱ collagen |
| 基金项目:辽宁省自然科学基金项目(201020214) |
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| 中文摘要: |
| 摘要 目的：探讨骨保护素对激素性股骨头坏死患者功能恢复及血清抗酒石酸酸性磷酸酶(TRAP)和Ⅱ型胶原羧基端端肽(CTX-Ⅱ)水平的影响。方法：选取2014年1月~2016年6月我院骨科收治的130例激素性股骨头坏死患者作为研究对象，采取随机数字表将其分成两组，每组65例。两组患者均给平卧床、患肢持续皮牵引治疗，观察组在此基础上联合使用骨保护素治疗，比较两组临床疗效、功能恢复情况以及治疗前后骨密度、血清TRAP与CTX-Ⅱ水平。结果：观察组治疗优良率为90.77%，相对于对照组的72.31%明显上升(P<0.01)。两组治疗后股骨头局部骨密度均有上升(P<0.01)，其中观察组上升更为明显(P<0.01)；观察组治疗后腰椎平均骨密度与治疗前相比有明显上升(P<0.01)，对照组无明显变化(P>0.05)。两组治疗后血清TRAP与CTX-Ⅱ水平均较治疗前显著下降(P<0.01)，但观察组下降更为明显(P<0.01)。结论：骨保护素治疗激素性股骨头坏死可有效抑制骨吸收、增强骨密度、改善患髋关节功能。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of bone protective hormone on functional recovery and the level of serum tartrate resistant acid phosphatase (TRAP) and C-telopeptide fragments of type Ⅱ collagen (CTX-Ⅱ) of patients with steroid induced avascular necrosis of the femoral head. Methods: 130 cases of steroid induced femoral head necrosis patients treated in our hospital from January 2014 to June 2016 were selected as the research subjects and divided into two groups with the method of random number table, 65 cases in each group. Both groups of patients were given conservative treatment, on the basis of which, the observation group was combined with the use of bone protective treatment. The clinical efficacy, functional recovery, bone mineral density, serum TRAP and CTX-Ⅱ levels were compared between the two groups. Results: The excellent and good rate of observation group was 90.77%, which increased significantly compared with 72.31% in the control group (P<0.01). The local bone mineral density of both groups both increased after the treatment (P<0.01). The observation group increased more significantly (P<0.01). The average bone mineral density of observation group significantly increased compared with that before the treatment (P<0.01). There was no significant change in the control group (P>0.05). The serum levels of TRAP and CTX-Ⅱ after the treatment in both groups significantly decreased compared with those before treatment (P<0.01), but the observation group decreased more significantly (P<0.01). Conclusion: Bone protective hormone could effectively inhibit bone resorption, increase bone density and improve the function of the hip joint in the treatment of steroid induced avascular necrosis of the femoral head. |
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