| 高 波,雷 光,翟春红,程 实,王 蕾.核医学肾动态显像和血清Cys C在评价肾积水患者肾功能中的临床应用[J].现代生物医学进展英文版,2017,17(11):2054-2056. |
| 核医学肾动态显像和血清Cys C在评价肾积水患者肾功能中的临床应用 |
| Clinical Application of Renal Dynamic Imaging and Serum Cystatin C for Evaluation of Renal Function in Patients with Hydronephrosis |
| Received:August 15, 2016 Revised:September 07, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.11.013 |
| 中文关键词: 肾积水 肾动态显像 Cys C |
| 英文关键词: Hydronephrosis Renal dynamic imaging Cys C |
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| 中文摘要: |
| 摘要 目的：探讨核医学肾动态显像和血清胱抑素C（Cys C）在评价肾积水患者肾功能中的临床应用。方法：选择2014年1月至2015年1月我院收治的肾积水患者70例，依据肾积水程度将患者分为轻度积水组（21例）、中度积水组（26例）、重度积水组（23例）三组，选择同期我院体检中心的健康成人20例作为对照组，所有研究对象分别通过肾动态显像和双血浆法测量肾小球率过滤（GFR），分别记为I-GFR和rGFR，采用酶联免疫吸附法和血生化分析仪分别检测血清Cys C和尿素氮（BUN）、血肌酐（SCr）。结果：各组各指标比较差异均有统计学意义（均P<0.05），肾积水患者r-GFR、I-GFR显著低于对照组患者，Cys C、BUN、SCr均显著高于对照组患者，差异有统计学意义（均P<0.05）；不同程度患者r-GFR、Cys C和SCr差异有统计学意义（均P<0.05），其中，重度积水组>中度积水组>轻度积水组，差异有统计学意义（均P<0.05）；重度积水组I-GFR和BUN均高于轻度积水组和中度积水组,差异有统计学意义（均P<0.05）；rGFR和I-GFR与肾积水程度呈负相关(r=-0.967、-0.754，P=0.000、0.000)，Cys C、BUN和SCr与肾积水程度呈正相关（r=0.883、0.627、0.671，P=0.000、0.002、0.001）。结论：核医学肾动态显像在评价轻度肾积水患者肾功能时更敏感，而血清Cys C在区分中、重度肾积水患者时更加准确，上述两指标作为替代双血浆法的检测方法在临床上应该互为补充，方能使诊断更加准确。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical application of renal dynamic imaging and serum Cystatin C for evaluation of re- nal function in patients with hydronephrosis. Methods: 70 patients with hydronephrosis were enrolled from Jan.2014 to Jan.2015, then di- vided into three groups, which were Mild- group (n=21), Moderate- group (n=26) and Severe- group (n=23), according to degree of hy- dronephrosis, and 20 healthy subjects were enrolled at same time as control group. All of the subjects were calculated glomerular filtra- tion rate (GFR) by renal dynamic imaging and two-sample method which were recorded as I-GFR and rGFR. Cys C were detected with ELISA kit, blood urea nitrogen (BUN) and serum creatinine (SCr) were detected by automatic biochemistry analyzer. Results: There were significant differences in the indexes of each group (all P<0.05), patients with r-GFR and I-GFR in patients with renal water were signifi- cantly lower than those in the control group, Cys C, BUN, SCr were significantly higher than those in the control group, the difference was statistically significant (all P<0.05); There were significant differences in r-GFR, Cys C and SCr in patients with different degrees (all P<0.05), among them, severe-group>moderate-group>mild-group, the difference was statistically significant (all P<0.05); The I-GFR and BUN of Severe-group were all higher than those in mild-group and moderate-group, the difference was statistically significant (all P<0.05); rGFR and I-GFR were negatively correlated with the degree of renal water(r=-0.967, -0.754; P=0.000, 0.000), Cys C, BUN and SCr were positively correlated with the degree of renal water (r=0.883, 0.627, 0.671; P=0.000, 0.002, 0.001). Conclusion: The renal dynamic imaging in the evaluation of renal function in patients with mild hydronephrosis was more sensitive, while Cys C in distinguishing severe and moderate hydronephrosis was more accurate. As the alternative methods for the detection of two-sample method in clinic should complement each other, can make the diagnosis more accurate. |
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