| 杨国曦,陈晓勇,朱锦宇,朱庆生,杨重飞.CD11b表达与人工髋关节置换术后无菌性松动的相关性分析[J].现代生物医学进展英文版,2017,17(11):2046-2049. |
| CD11b表达与人工髋关节置换术后无菌性松动的相关性分析 |
| Analysis of the Correlation between CD11b Expression and Aseptic Loosening |
| Received:November 03, 2016 Revised:November 26, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.11.011 |
| 中文关键词: CD11b 无菌性松动 相关性分析 |
| 英文关键词: CD11b Aseptic loosening Correlation analysis |
| 基金项目:国家自然科学基金项目（81301541） |
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| 中文摘要: |
| 摘要 目的：分析髋关节周围滑膜组织CD11b表达水平与人工髋关节置换术后无菌性松动的相关性。方法：以2006年5月至2016年5月于西京医院接受人工髋关节置换的患者为研究对象，对其髋关节周围滑膜组织进行CD11b免疫组化染色，并随访术后5年和10年无菌性松动的发生情况，通过单因素分析及logistic回归分析讨论CD11b表达与无菌性松动之间的相关性。结果：共300例患者纳入研究，全部获得随访，CD11b表达阳性患者163例，阳性率为54.33 %；术后5年松动患者29例，术后5年无菌性松动发生率为9.67 %；术后10年无菌性松动患者49例，术后10年无菌性松动发生率为16.33 %；单因素分析结果表明CD11b表达阳性患者5年及10年松动率均高于CD11b表达阴性患者（P<0.05）；logistic回归分析结果表明CD11b过表达是髋关节置换术后无菌性松动发生的危险因素。结论：髋关节周围滑膜组织CD11b过表达是人工髋关节置换术后无菌性松动发生的危险因素，该分子或可作为无菌性松动的辅助诊断指标及潜在治疗靶点。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the correlation between CD11b expression and aseptic loosening. Methods: CD11b of synovial tissue around the hip joint from patients received total hip replacement during 2006 May to 2016 May were immunohistochemical stained, and a follow-up was performed to detect the occurrence of aseptic loosening. Single factor analysis and logistic regression analy- sis was used to investigate the correlation between CD11b expression and aseptic loosening occurrence. Results: 300 patients were fol- lowed up; the number of CD11b positive patients was 163, CD11b postive ratio was 54.33 %; 29 patients(9.67 %) suffered from aseptic loosening 5 years after operation and 49 patients(16.33%) suffered from aseptic loosening 10 years after operation; the aseptic loosening raio of CD11b-positive patients was higher than that of CD11b-negative patients(P<0.05); logistic regression analysis suggested that CD11b over-expression was the risk factor of aseptic loosening. Conclusion: CD11b over-expression was the risk factor of aseptic loos- ening and CD11b might be an auxiliary diagnosis indicator and potential therapeutic target of aseptic loosening after total hip replace- ment. |
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