| 程喆歆,梁庆成,吴 云,丛 林,朱 丹.阿尔茨海默病的发病机制及药物治疗的研究进展[J].现代生物医学进展英文版,2017,17(10):1981-1985. |
| 阿尔茨海默病的发病机制及药物治疗的研究进展 |
| Research Progress in the Pathogenesis and Medication of Alzheimer's Disease |
| Received:April 05, 2016 Revised:April 30, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.10.048 |
| 中文关键词: 阿尔茨海默病 发病机制 药物治疗 研究进展 |
| 英文关键词: Alzheimer's disease Pathogenesis Medication Research progress |
| 基金项目: |
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| 中文摘要: |
| 摘要：阿尔茨海默病(Alzheimer's disease，AD)是一种慢性进行性神经变性疾病，早期临床表现为近期记忆力下降，后来逐渐发展为生活不能自理最终死亡。目前，有许多种假说阐述其发病机制，如?茁-淀粉样蛋白、载脂蛋白E、一些金属元素、炎症因子等，但都不全面，也有人认为其可能与朊蛋白有关。部分药物被用于治疗AD，如美金刚、胆碱酯酶抑制剂等，但疗效均不显著。一些新的治疗理念和方法也逐渐被发现，如脑源性神经生长因子(brain-derived neurotrophic factor，BDNF)以及免疫疗法等，但其远期疗效还需进一步证实，且一些副作用还并未被人们所知晓。本文主要对阿尔茨海默病的发病机制及药物治疗的研究进展进行了综述。 |
| 英文摘要: |
| ABSTRACT: Alzheimer's disease(AD) is a chronic progressive neurodegenerative disorder. The early clinical manifestations is the loss of short-term memory, then progress to fail to take care of himself even lead to death. At present, there are several hypothesis explaining the pathogenesis of AD, such as ?茁-amyloid, Apolipoprotein E, some metal elements, inflammatory factor, and so on. But all are not comprehensive. Prion protein is also considered to be involved in the pathogenesis of AD. Some drugs have been used to treat AD, such as Memantine, Cholinesterase inhibitors and so on, but the results are not significant, some new treatment concept and method have also been identified, such as brain-derived neurotrophic factor(BDNF), immunotherapy and so on. But the long term effect still need to be observed and some side effect haven't been known. This article mainly reviews the research progress in the pathogenesis and medication of Alzheimer's disease. |
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