| 唐 静,刘 健,肖 霞,梅耀玲,左培媛.胰岛素联合百令胶囊对早期糖尿病肾病患者临床疗效的影响[J].现代生物医学进展英文版,2017,17(10):1927-1930. |
| 胰岛素联合百令胶囊对早期糖尿病肾病患者临床疗效的影响 |
| Effect of Insulin combined with One Hundred Capsule on the Clinical Effect of Early Diabetic Nephropathy |
| Received:September 15, 2016 Revised:September 30, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.10.034 |
| 中文关键词: 糖尿病肾病 胰岛素 百令胶囊 尿蛋白 CD68 |
| 英文关键词: Diabetic nephropathy Insulin Corbrin Capsule Urinary protein CD68 |
| 基金项目:四川省自然科学基金项目(20120206) |
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| 中文摘要: |
| 摘要 目的：探讨胰岛素联合百令胶囊对早期糖尿病肾病患者临床疗效的影响。方法：选取前来我院就诊的已确诊的早期糖尿病肾病患者70例，随机分为对照组和治疗组，每组35例。对照组给予门冬胰岛素治疗；治疗组在对照组基础上联合百令胶囊。比较治疗前后两组患者的血糖、尿白蛋白排泄率(UAER)、24 h尿蛋白定量、β2—微球蛋白（β2-MG）、血肌酐（SCr）、尿素氮（BUN）、T淋巴细胞（CD68）水平的变化情况，记录分析两组患者的临床疗效。结果：治疗组总有效率明显高于对照组(P＜0.05)。治疗后，两组患者血糖、UAER、24h尿蛋白定量、β2-MG、SCr、BUN、CD68水平均较治疗前显著降低，且治疗组低于对照组(P＜0.05)。结论：胰岛素和百令胶囊的联合应用能有效控制早期糖尿病肾病患者的血糖水平，减少肾脏损伤，缓解临床症状，提高临床疗效。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of insulin combined with one hundred Capsule on the clinical effect of early diabetic nephropathy. Methods: 70 patients with early diabetic nephropathy in our hospital were selected and randomly divided into the control group and the experiment group with 35 cases in each group. The control group was treated by Insulin aspart and the experiment group was treated on the base of the control group with Corbrin Capsule. The blood glucose, UAER, 24 h urinary protein quantitation, beta 2-MG, SCr, BUN, CD68 levels and clinical curative effect were compared. Results: The total effective rate of treatment group was significantly higher than that of the control group(P＜0.05). Compared with before treatment, the blood glucose, UAER, 24 h urinary protein quantitation, beta 2-MG, SCr, BUN, CD68 levels were lower(P＜0.05), which were lower in the experiment than those of the control group(P＜0.05). Conclusion: The combination of insulin and one hundred capsule could effectively control the blood glucose level in patients with early diabetic nephropathy, reduce the renal damage, relieve the clinical symptoms and improve the clinical efficacy. |
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