| 张 梅,王 刚,武青青,杜娟花,姚晓雷.CRP联合CA72-4, CEA, CA19-9检测对胃癌早期诊断的临床价值[J].现代生物医学进展英文版,2017,17(10):1896-1899. |
| CRP联合CA72-4, CEA, CA19-9检测对胃癌早期诊断的临床价值 |
| Clinical Value of CRP combined with CA72-4, CEA, CA19-9 Detection in the Early Diagnosis of Gastric Cancer |
| Received:December 07, 2016 Revised:December 30, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.10.025 |
| 中文关键词: 胃癌 诊断 C反应蛋白 胃癌抗原 癌胚抗原 糖类抗原 |
| 英文关键词: Gastric cancer Diagnosis CRP Tumor marker Clinical pathology |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探究C反应蛋白(CRP)联合胃癌抗原(CA72-4)、癌胚抗原(CEA)、糖类抗原(CA19-9)检测对胃癌早期诊断的临床价值。方法：选择2014年3月～2016年6月我院收治的胃癌患者(103例)为胃癌组，包括早期胃癌患者30例，中晚期患者73例；同期就诊于我院的良性胃病患者为良性胃病组(61例)，另选择20例年龄、性别相匹配的健康体检人群为健康对照组。比较三组人群血清C反应蛋白(CRP)、CA72-4、CEA、CA19-9水平，并探讨其表达与胃癌患者临床病理特征之间的关系。结果：早期胃癌组、良性胃病组患者的血清CRP、肿瘤标志物CA72-4、CEA、CA19-9的表达水平及阳性检测率均显著高于健康对照组(P＜0.05)；早期胃癌组的上述指标显著高于良性胃病组(P＜0.05)。肿瘤分化程度低、发生转移、临床分期为Ⅲ，Ⅳ期胃癌患者的血清CRP、CA72-4、CEA、CA19-9阳性检测率显著高于肿瘤高分化、未发生转移、临床分期为Ⅰ、Ⅱ期的胃癌患者(p＜0.05)。血清CRP、CA72-4、CEA、CA19-9联合检测胃癌的敏感度92.23%，特异度为90.85%，联合检测敏感度显著高于CRP(68.93%)、CA72-4(71.84%)、CEA(77.67%)、CA19-9(59.22%)单项检测(p＜0.05)。结论：血清CRP、CA72-4、CEA、CA19-9水平与胃癌的临床病理特征密切相关，联合检测能显著提高检测灵敏度，有利于胃癌早期诊断。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical value of CRP combined with tumor marker detection in early diagnosis of gastric cancer. Methods: 103 patients treated and diagnosed as early gastric cancer in our hospital from March, 2014 to June, 2016 were enrolled in gastric cancer group, including early gastric cancer 30 cases, middle and advanced gastric cancer 73 cases; other 61 patients with benign gastric disease was enrolled in benign gastric disease group; another 20 health people was control group. The level of serum CRP, tumor markers were compared among three groups, and its relevance to clinical pathology of gastric cancer patients was also discussed. Results: The level and positive rate of serum CRP, CA72-4, CEA, CA19-9 of gastric cancer group and benign gastric disease group were significantly higher than control group, and those of gastric cancer group were obviously higher than benign gastric disease group(p＜0.05); gastric cancer patients with lower tumor differentiation, metastasis, Ⅲ，Ⅳ stages presented higher serum CRP, CA72-4, CEA, CA19-9 level(p＜0.05); the sensitivity and specificity of combined detection of serum CRP and CA72-4, CEA, CA19-9was 92.23% and 90.85%, respectively, which were significantly higher than single detection (p＜0.05). Conclusion: The level of serum CRP, CA72-4, CEA, CA19-9was closely related to clinical pathology, combined detection of serum CRP and CA72-4, CEA, CA19-9 could effective improve the sensitivity, which will benefit the early diagnosis of gastric cancer. |
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