| 张少卿,杨冠琦,丁晓欢,修 婵,赵兴伟.黄芪注射液辅助治疗小儿病毒性心肌炎的临床疗效分析[J].现代生物医学进展英文版,2017,17(10):1863-1865. |
| 黄芪注射液辅助治疗小儿病毒性心肌炎的临床疗效分析 |
| Clinical Effects of Adjuvant Treatment by Astragalus Injection on Viral Myocarditis |
| Received:September 06, 2016 Revised:September 25, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.10.016 |
| 中文关键词: 小儿病毒性心肌炎 黄芪注射液 血肌钙蛋白Ⅰ IL-10 IL-6 |
| 英文关键词: Viral myocarditis in children Astragalus injection Serum cardiac troponin Ⅰ IL-10 IL-6 |
| 基金项目:辽宁省科学技术计划项目(20120620) |
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| 中文摘要: |
| 摘要 目的：探讨黄芪注射液辅助治疗小儿病毒性心肌炎患者的临床疗效及其可能机制。方法：选择我院确诊并治疗的病毒性心肌炎小儿患者72例作受试者，按随机数字表法分为两组，对照组36例予以西医常规治疗，治疗组36例在常规治疗基础上予联合黄芪注射液治疗。观察两组患者的临床疗效，比较患者治疗前后血清肌钙蛋白Ⅰ、乳酸激酶(CK)、乳酸激酶同工(CK-MB)、肿瘤坏死因子-α（TNF-α）、IL-10及IL-6水平的变化。结果：治疗后，对照组总有效率显著低于治疗组(P＜0.05)；与对照组比较，治疗组治疗后血肌钙蛋白Ⅰ、CK、CK-MB、TNF-α及IL-6水平显著降低，IL-10水平升高，差异具有统计学意义(P＜0.05)。结论：黄芪注射液的辅助应用可显著提高小儿病毒性心肌炎患者的临床疗效，这可能与其降低患者血清TNF-α、IL-6水平及提高IL-10水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effects and mechanism of auxiliary application by astragalus injection on the serum levels of cardiac troponin Ⅰ, IL - 10 and IL - 6 in the children with viral myocarditis. Methods: 72 children with viral myocarditis who were treated in our hospital were selected and randomly divided into two groups, 36 cases in the control group were treated with western medicine routine treatment, while 36 cases in the experiment group were treated on the base of the conventional treatment with astragalus injection 10 mL, intravenous drip once a day, both groups of patients were continuously treated for 4 weeks. The clinical efficacy, serum cardiac troponin Ⅰ, lactic acid kinase (CK), lactic acid kinase co-workers (CK - MB), TNF -α, IL - 10 and IL - 6 levels were compared between two groups before and after treatment. Results: The total effective rate of control group was lower than that of the experiment group (P < 0.05). Compared with the control group, the serum cardiac troponin Ⅰ, CK, CK - MB, TNF -α and interleukin family levels of the experiment group statistically reduced (P < 0.05). Conclusion: Astragalus injection auxiliary application could enhance the immunity, and improve the clinical efficacy of children with viral myocarditis, which could be rated to the decrease of serumTNF-α, IL-6 levels and enhancement of serum IL-10 level. |
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