| 黄 勇,刘丽珍,金忠芹,唐伟国,武庆斌.奥美拉唑联合多潘立酮治疗小儿胃食管反流病的疗效观察[J].现代生物医学进展英文版,2017,17(10):1859-1862. |
| 奥美拉唑联合多潘立酮治疗小儿胃食管反流病的疗效观察 |
| The Observation of the Clinical Efficacy of Omeprazole and Domperidone for Gastroesophageal Reflux Disease in Children |
| Received:August 31, 2016 Revised:September 20, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.10.015 |
| 中文关键词: 奥美拉唑 多潘立酮 小儿胃食管反流病 |
| 英文关键词: Omeprazole Domperidone Gastroesophageal reflux disease |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探究奥美拉唑联合多潘立酮治疗小儿胃食管反流病的临床疗效。方法：选择2012年10月～2015年12月期间内因胃食管反流病入院接受治疗的患儿80例，所有患儿均采用奥美拉唑和多潘立酮联合治疗。在治疗前和治疗后8周内，观察患者的临床治疗效果、24 h食管下段pH值监测、电子胃镜检查和内镜下黏膜活检。结果：研究对象用药前后呕吐、恶心、反酸、上腹痛、烧心、胸骨后痛、咳嗽、气喘等八项临床症状得到了明显的改善，甚至消失，差异具有统计学意义(P<0.05)；患儿治疗后的反流次数、反流时间≥5 min的次数、最长反流时间、总PH<4时间占总时间的百分比以及综合评分均较治疗前明显降低，差异具有统计学意义(t=33.385、40.862、47.710、21.806、53.508，P<0.05)；与治疗前对比，研究对象治疗后有1例存在重度反流性食管炎未能恢复，28例存在不同程度改善，43例完全恢复，差异有统计学意义(Z=37.775，P<0.05)；不良反应出现5例（3例轻微腹泻、2例轻微腹痛），发生率为6.25%。结论：奥美拉唑联合多潘立酮治疗小儿胃食管反流病的临床效果较为显著，能够明显改善小儿胃食管反流症状，安全性较高，值得在临床上进一步推广使用。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the clinical efficacy of omeprazole combined with domperidone in the treatment of gastroesophageal reflux disease in children. Methods: From October 2012 to December 2015, 80 cases of children with gastroesophageal reflux disease admitted into hospital for treatment were included into the study, which omeprazole combined with domperidone in treating. Before treatment and after treatment of 8 weeks, the clinical therapeutic effect of patients, 24 h lower esophageal pH monitoring,electronic gastroscopy and endoscopic mucosal biopsy were observed. Results: there was a certain degree of improvement after treatment for vomiting, nausea, acid regurgitation, upper abdominal pain, heartburn, retrosternal pain, cough, asthma and so on eight clinical symptoms, the data were statistically significant (P<0.05). Cases with indicator including reflux times, times with reflux time≥5 times, the longest reflux time, the total PH<4 percentage of time and comprehensive score index after the treatment were significantly lower than before treatment, the data difference was statistically significant (t=33.385, 40.862, 47.710, 21.806, 53.508, P<0.05). By endoscopic biopsy, only 1 patient had severe anti reflux esophagitis failed to restore, and 28 cases had different degrees of improvement, 43 cases recovered completely, the difference was statistically significant (Z=37.775, P<0.05). Adverse reactions occurred in 5 cases (3 cases of mild diarrhea, 2 cases of mild abdominal pain, the incidence was 6.25%. Conclusion: The treatment of cases with gastroesophageal reflux disease combined with omeprazole and domperidone, clinical effect was significant.Children with gastroesophageal reflux symptoms can be significantly improved, higher safety of clinical treatment. Therefore, it is worthy of clinical further promotion to use. |
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