| 谢 宁,曾化桂,田 璨,吴 晖,欧阳取长.循环肿瘤细胞在40例晚期转移性乳腺癌患者中的检测意义[J].现代生物医学进展英文版,2017,17(10):1856-1858. |
| 循环肿瘤细胞在40例晚期转移性乳腺癌患者中的检测意义 |
| Detection Value of Circulating Tumor Cells in 40 Patients with Metastatic Breast Cancer |
| Received:August 31, 2016 Revised:September 23, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.10.014 |
| 中文关键词: 循环肿瘤细胞 转移性乳腺癌 无疾病进展时间 |
| 英文关键词: Circulating Tumor Cells Metastatic breast cancer PFS |
| 基金项目:湖南省卫计委科研基金项目（C2015-47）；湖南省科技厅2014年度课题,湘财企指【2014】4号(2014SK3012) |
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| 中文摘要: |
| 摘要 目的：探讨循环肿瘤细胞CTCs在晚期转移性乳腺癌中的应用价值。方法：CellSearch系统检测本院40例复发转移性乳腺癌患者的CTCs水平，比较复发转移性乳腺癌患者血液中CTCs的差异，分析复发转移性乳腺癌患者CTCs与其疾病特征及预后的关系。结果：CellSearch系统检测复发转移性乳腺癌患者外周血CTCs阳性率达42.5%；在复发转移性乳腺癌患者中，CTCs≥5个/7.5 mL者的肝脏转移、骨转移、转移灶≥3处均较CTCs<5个/7.5 mL者更高（P<0.05），前者的PFS较之后者也表现出强烈的缩短趋势（X2=3.573，P=0.059），而肺转移、淋巴结转移、脑转移、胸壁复发、受体及HER2表达在两组间无差异。结论：CellSearch系统展现出较好的检测复发转移性乳腺癌患者外周血CTCs的能力。在复发转移性乳腺癌患者中，CTCs的高检出率与腹腔脏器转移、肝转移、骨转移相关。CTCs≥5个/7.5 mL患者的预后很可能要差于CTCs<5个/7.5 mL者。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the value of circulating tumor cells in patients with metastatic breast cancer. Methods: Levels of CTCs of 40 patients with metastatic breast cancer were detected by the CellSearch system, relationships of the characteristics and prognosis of the disease and the level of CTCs were also analysed. Results: The positive rate of CTCs detected by the Cell Search system was 42.5%. Patients with a CTCs level ≥5 /7.5 mL were more likely have metastatic sites such as lung, bone and ≥3 metastatic sites than those patients with a level of <5 /7.5 mL, but not for metastatic sites such as lung,lymph node, brain and chest wall, and hormone receptor expression and HER2 expression were irrelevant with levels of CTCs. Patients with a higher CTCs level showed a strong trend of shorter PFS(X2=3.573, P=0.059). Conclusion: Cell Search system showed a reliable ability in detecting CTCs. In patients with locally advanced or metastatic breast cancer, high level of CTCs is associated with liver metastasis, bone metastasis, or ≥3 metastatic sites. The Prognosis of patients with CTCs ≥5/7.5 mL is probably poorer than those with CTCs <5/7.5 mL. |
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