| 李士英,熊佳时,何忠惠,顾春荣,朱 英.中性粒细胞-淋巴细胞比率与老年NSCLC患者临床病理及预后的相关性分析[J].现代生物医学进展英文版,2017,17(10):1846-1848. |
| 中性粒细胞-淋巴细胞比率与老年NSCLC患者临床病理及预后的相关性分析 |
| Correlative Analysis of Neutrophil/lymphocyte Ratio with the Clinicopathology and Prognosis of Elderly Patients with Non-small Cell Lung Cancer |
| Received:September 21, 2016 Revised:October 19, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.10.011 |
| 中文关键词: 中性粒细胞-淋巴细胞比率 非小细胞肺癌 老年 临床病理 预后 |
| 英文关键词: Neutrophil/lymphocyte ratio Non-small cell lung cancer Elderly Clinicopathology Prognosis |
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| 中文摘要: |
| 摘要 目的：研究中性粒细胞-淋巴细胞比率(NLR)与老年非小细胞肺癌(NSCLC)患者临床病理及预后的相关性分析。方法：回顾性分析我院收治的68例老年NSCLC患者的临床病理资料。根据化疗前NLR分为低NLR组(<2.95)、高NLR组(≥2.95)。比较两组患者临床病理特点及无病生存期(DFS)，并分析预后的影响因素。结果：与低NLR组比较，高NLR组临床分期Ⅳ期、吸烟及淋巴转移的比例更大(P<0.05)，而两组间年龄、性别、病理类型及合并症比较差异均无统计学意义(P>0.05)。低NLR组中位DFS为7.2个月(95%CI: 5.9~8.4)，显著高于高NLR组中位DFS 6.7个月(95%CI: 5.4~7.9)(P<0.05)。淋巴转移、NLR是老年NSCLC患者DFS的独立危险因素，而年龄、化疗次数则是独立保护因素(P<0.05)。结论：NLR与老年NSCLC患者的临床分期和淋巴结转移有明显相关性，并可作为预后评估参考指标之一。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the correlation of neutrophil/lymphocyte ratio (NLR) with the clinicopathology and prognosis of elderly patients with non-small cell lung cancer (ARDS). Methods: The clinical data of 68 cases of elderly patients with NSCLC in our hospital were retrospectively analyzed. According to the NLR before chemotherapy, patients were divided into the low NLR(<2.95)group and the high NLR(≥2.95)group. The clinicopathological characteristics and disease-free survival (DFS) were compared between two groups, and the influencing factors of prognosis were analyzed. Results: Compared with low NLR group, higher proportion of clinical stage Ⅳ, smoking and lymph node metastases were observed in high NLR group (P<0.05), while no statistically significant difference was found in the age, sex, pathological types and complications between two groups (P>0.05). The median DFS in low NLR group was 7.2 months (95% CI: 5.9~8.4), which was significantly longer than 6.7 months (95% CI: 5.4~7.9) in high NLR group (P<0.05). Lymph node metastases and NLR were the independent risk factors of DFS in elderly patients with NSCLC, while age, number of chemotherapy were independent protection factors (P<0.05). Conclusion: NLR was obviously correlated with the clinical stage and lymph node metastases of elderly patients with NSCLC, it could also be used as evaluation index of prognosis. |
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