| 张 艺,邹 健,徐少勇,张 娟,翟佳佳,李晓苗.PR间期在糖尿病视网膜病变早期诊断中的价值[J].现代生物医学进展英文版,2017,17(10):1843-1845. |
| PR间期在糖尿病视网膜病变早期诊断中的价值 |
| Role of PR Interval in the Early Diagnosis of Diabetic Retinopathy |
| Received:September 13, 2016 Revised:October 10, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.10.010 |
| 中文关键词: 2型糖尿病 糖尿病视网膜病变 PR间期 内皮功能障碍 |
| 英文关键词: Type 2 diabetes mellitus Diabetic retinopathy (DR) PR interval Endothelial dysfunction |
| 基金项目:国家自然科学基金项目（81573746） |
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| 中文摘要: |
| 摘要 目的：探讨PR间期在糖尿病视网膜病变早期诊断中的价值。方法：选取2型糖尿病(T2DM)患者578例，依据眼底照相结果，将研究对象分为无视网膜病变(NDR)组345例、单纯型视网膜病变组(BDR)组191例、增殖型视网膜病变组(PDR)组42例。比较各组一般资料及PR间期长度，进行统计分析。结果：所有患者的PR间期均值为162.76±20.10 ms。PDR组和BDR组患者PR间期的平均长度显著高于NDR组(P <0.001)。Logistic回归分析结果显示PR间期每延长1 ms，T2DM患者患得DR的风险增加2.7%倍(OR=1.027，95%CI：1.016～1.038，P<0.001)；PR＞163 ms是PR≤163 ms的T2DM患者患得DR风险的2.727倍(OR=2.727 95%CI:1.936～3.842,P<0.001)。结论：心电图PR间期与糖尿病视网膜病变有显著的相关性，可以作为一个简单、无创的辅助检查用于早期筛查糖尿病视网膜病变。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the relationship between PR interval and diabetic retinopathy (BDR). Methods: A total of 578 cases of patients with type 2 diabetes mellitus were selected and divided into two groups according to their fundus photography results: patients without diabetic retinopathy (NDR group, n=345), patients with diabetic retinopathy (BDR group, n=191), patients with proliferative diabetic retinopathy (PDR group, n=42). General data and the length of the PR interval were compared and analyzed among three groups. Results: The mean PR interval of all patients was 162.76±20.10 ms. PR interval of patients with retinopathy and with proliferative diabetic retinopathy were significantly greater than those without retinopathy (P<0.001). Logistic regression analysis showed that the risk of DR for T2DM patients with PR＞163 ms was 2.727 time higher than those with PR≤163 ms (OR=2.727 95%CI:1.936～3.842,P<0.001). Conclusion: Electrocardiogram PR interval might be used as a simple, available and noninvasive method for screening of diabetic retinopathy. |
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