| 李 卿,王红梅,张瑜娟,刘安文,闵卫平.耗竭性T细胞在肿瘤中的作用[J].现代生物医学进展英文版,2017,17(9):1788-1792. |
| 耗竭性T细胞在肿瘤中的作用 |
| The Role of Exhausted T Cells in Tumor |
| Received:April 28, 2016 Revised:May 23, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.09.051 |
| 中文关键词: 耗竭性T细胞 肿瘤 免疫负调控 免疫调控点 |
| 英文关键词: Exhausted T cells Tumor Negative immunoregulation Immune check point |
| 基金项目:国家自然科学基金项目（81160286; 91229119)；江西省研究生创新基金项目（YC2014-B024） |
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| 中文摘要: |
| 摘要：耗竭性T细胞（exhausted T cells）是一群效应功能减弱，持续表达抑制性受体的T细胞，在肿瘤中表现为T细胞功能缺陷状态，主要特征为一系列抑制性受体表达增加及细胞因子分泌减少。耗竭性T细胞主要通过细胞表面的抑制性分子，细胞因子和免疫调节细胞类型改变等参与肿瘤免疫负调控，从而引起肿瘤免疫逃逸。而T细胞耗竭状态并非不可逆转，应用相应单克隆抗体靶向免疫调控点可以有效逆转耗竭性T细胞，恢复机体抗肿瘤免疫反应，提高肿瘤控制率。因此，通过逆转肿瘤患者体内的耗竭性T细胞可能是肿瘤免疫治疗的新途径之一。 |
| 英文摘要: |
| ABSTRACT: T cell exhaustion is defined by poor effector function, sustained expression of inhibitory receptors and decrease of cy- tokine. It is a state of T cell dysfunction that arises during cancer. T cell exhaustion is associated with negative immunoregulatory path- ways which can be grouped into three main categories: cell surface inhibitory receptors, cytokine and immunoregulatory cell types. It can induce immune escape in tumor. But exhausted T cells is not irreversible. Blocking the appropriate pathways with monoclonal antibody may reverse the dysfunction of exhausted T cells, improve the anti-tumor immunity and tumor control probability. It is a new im- munotherapy to treat cancer by reversing the exhausted T cells in cancer patients. |
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