| 董笑克,刘铜华,郭翔宇,段 颖,傅 瑶,许光远,洪明昭.FoxO1对下丘脑摄食中枢的影响研究进展[J].现代生物医学进展英文版,2017,17(9):1780-1783. |
| FoxO1对下丘脑摄食中枢的影响研究进展 |
| The Effects of FoxO1 on Hypothalamic Feeding Center |
| Received:June 10, 2016 Revised:June 28, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.09.049 |
| 中文关键词: FoxO1 摄食中枢 POMC AgRP |
| 英文关键词: FoxO1 Feeding center POMC AgRP |
| 基金项目:国家自然科学基金项目（81303130）；北京市科技新星（Z141107001814011）；东方新星（PFRC2014C06） |
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| 中文摘要: |
| 摘要：下丘脑是人体的摄食中枢，它通过抑制食欲的阿黑皮素原（POMC）神经元和促进食欲的神经肽相关蛋白（AgRP）神经元调节摄食及能量代谢。叉头转录因子O亚族1（FoxO1）是胰岛素信号通路和瘦素信号通路中重要的调节蛋白，FoxO1的生理作用是促进下丘脑Agrp基因表达、抑制Pomc基因表达，抑制瘦素信号通路的转录激活因子3(STAT3)蛋白对Pomc基因转录的促进作用，从而促进食欲。瘦素和胰岛素均可激活经典的IRS/PI(3)K/Akt信号通路，使FoxO1磷酸化失去活性，抑制食欲。此外，沉默信息调节因子Sirt1也可以通过去乙酰化，影响FoxO1的转录活性。本文综述了胰岛素、瘦素、Sirt1通过FoxO1调节下丘脑摄食中枢的作用机制。 |
| 英文摘要: |
| ABSTRACT: Hypothalamus is the feeding center in human, it regulates food intake and energy metabolism by inhibiting the POMC(proopiomelanocortin) neurons that suppresses the appetite and promoting neuropeptide Y(NPY)/AgRP(agouti-related peptides) neurons that stimulates the appetite. FoxO1(transcription factor O subfamily 1) is an important regulator of insulin signaling pathway and leptin signaling pathway, it's physiological function is promoting the expression of Agrp gene and inhibits the expression of Pomc gene in hy- pothalamus, in addition it can inhibit the Promotion of STAT3(signal transducer and activator of transcription-3) protein on the transcrip- tion of POMC gene through leptin signaling pathway, eventually promotes the appetite. Both leptin and insulin can activate the classical IRS/PI (3) K/Akt signaling pathway, inhibit the activity of FoxO1, as a result, the appetite is inhibited. The acetylation regulation of Fox- O1 regulated by Sirt1 influences the transcription of FoxO1, effects on satiety. In this paper, we reviewed the mechanism of insulin, leptin and Sirt1 regulates hypothalamic feeding centers through FoxO1. |
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