| 王同帅,张 颖,黄金凤,余 昶,周美娟.MiRNA-664在肿瘤中的研究进展[J].现代生物医学进展英文版,2017,17(9):1776-1779. |
| MiRNA-664在肿瘤中的研究进展 |
| The Research Progress of MiRNA-664 in Cancer |
| Received:June 11, 2016 Revised:June 30, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.09.048 |
| 中文关键词: MicroRNA-664 增殖 信号通路 靶基因 |
| 英文关键词: MicroRNA-664 Proliferation Signaling Pathway Target gene |
| 基金项目:国家自然科学基金项目(81472922) |
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| 中文摘要: |
| 摘要：近年来，研究者在肿瘤发生发展的相关研究中发现，microRNA-664（miR-664）很可能是一个在肿瘤发展进程中发挥重要作用的miRNA。和肿瘤周围的正常组织相比，在不同的肿瘤组织中，miR-664的表达水平有些出现升高，有些出现降低，因此，其在不同肿瘤中发挥的生物学功能也不尽相同。相关研究证实，miR-664可影响细胞的增殖、周期调控、再生等过程，而其在代谢、凋亡和自噬等生物学功能中发挥何种作用仍需进一步深入探究。更加系统的深入研究miR-664将有助于发掘其在基因靶向诊断与治疗领域中的应用。 |
| 英文摘要: |
| ABSTRACT: MicroRNA-664(miR-664) may play an important role in the development of cancer according to recent studies. Aber- rant expression of miR-664 can be detected comparing with adjacent non-cancer tissues of patients, and it exerts different biological func- tions resting with its low or high expression in diseases. MiR-664 has been proved to be involved in proliferation, cell cycle, tissue regen- eration and other biological processes. However, the functions of miR-664 in the field of metabolism, apoptosis and autophagy need deeper investigation. Further studies on the specific functions of miR-664 will contribute to the application of MicroRNA-664 in the field of gene targeting diagnosis and therapy. |
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