| 韩 飞,武圣达,尉 丁,廖成功,陈志南,孔令敏.CD147在调节性T细胞中作用的研究进展[J].现代生物医学进展英文版,2017,17(9):1773-1775. |
| CD147在调节性T细胞中作用的研究进展 |
| Advance of CD147 in Regulatory T Cells |
| Received:April 30, 2016 Revised:May 23, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.09.047 |
| 中文关键词: 调节性T细胞 CD147 FoxP3 亲环素A |
| 英文关键词: Regulatory T cells CD147 FoxP3 CyPA |
| 基金项目:国家自然科学基金面上项目（81472632） |
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| 中文摘要: |
| 摘要：CD147是一种免疫球蛋白超家族，它与肿瘤侵袭和转染，类风湿性关节炎，病毒入侵，淋巴细胞的迁移和活化，老年痴呆症，疟原虫入侵等病理过程密切先关，已成为癌症等疾病的新型药物靶标分子。作为一个单次跨膜蛋白，CD147的多功能性依赖于它的胞外结构域以及细胞膜和细胞外多种分子的相互作用。有研究发现CD147可作为细胞膜受体并且在上皮细胞，肿瘤细胞和免疫T细胞中均有表达。其可作为T细胞亲环素受体并具有趋化T细胞的功能。近几年研究发现，CD147在调节性T细胞高表达并且具有标志性意义。该文就以作为活性调节性T细胞标志的CD147的潜在作用进展综述如下。 |
| 英文摘要: |
| ABSTRACT: CD147 belongs to the immunoglobulin superfamily of membrane receptors and is expressed in epithelial cells, cancer cells and T cells of the immune system. In T cells CD147 functions as a receptor for soluble cyclophilins and is involved in chemotaxis. We recently reported its expression to high levels and association with suppressive function in regulatory T cells. Here, we discuss its po- tential application as a marker of activated regulatory T cells. |
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