| 刘 剑,黄昌林,常 祺,张 莉,李延召.0期诊断技术对军事训练所致椎间盘源性下腰痛患者血清IL-1β, 6-keto-PGF1α及TNF-α水平的影响及其意义[J].现代生物医学进展英文版,2017,17(9):1753-1757. |
| 0期诊断技术对军事训练所致椎间盘源性下腰痛患者血清IL-1β, 6-keto-PGF1α及TNF-α水平的影响及其意义 |
| A Study on the Effect of Zero-stage Low back Pain Diagnostic Technique on the Serum Levels of IL-1β, 6-keto-PGF1α and TNF-α Discogenic Low Back Pain Induced by Military Training |
| Received:September 27, 2016 Revised:October 23, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.09.042 |
| 中文关键词: 0期诊断技术 椎间盘源性下腰痛 白介素1β 6酮前列腺素F1α 肿瘤坏死因子α |
| 英文关键词: Zero-stage diagnostic technique Discogenic low back pain Newly-enrolled soldiers IL-1β 6-keto-PGF1α TNF-α |
| 基金项目:济南军区联勤部卫生部基金项目(13BJYZ18) |
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| 中文摘要: |
| 摘要 目的：探讨0期诊断技术对军事训练所致椎间盘源性下腰痛患者血清白介素1β (IL-1β)、6酮前列腺素F1α(6-keto-PGF1α)、肿瘤坏死因子α(TNF-α)水平的影响及其意义。方法：随机抽取某部2014年度新兵一营306名新兵为实验组，新兵二营290名新兵为对照组，在入伍复检时为每名士兵抽血检测相关血清学指标，并建立健康档案。由经过技术培训的医师对实验组采用0期诊断技术，分别在新兵训练开始后的第2、4、6、8、10、12周进行0期椎间盘源性下腰痛的筛查，并实施相应的防治措施，同时，按照"军标"对所有实验对象进行下腰痛的常规诊治及登统计，对于诊断为0期椎间盘源性下腰痛阳性和椎间盘源性下腰痛阳性的士兵及时抽血检测IL-1β、6-keto-PGF1α、TNF-α血清值。结果：实验组椎间盘源性下腰痛总发生率(2.94 %)明显低于对照组(9.66 %)(x2=11.527，P<0.001)。在新训开始后的第8、10、12周，实验组椎间盘源性下腰痛的发生率均明显低于对照组(P<0.05)；实验组和对照组阳性士兵血清IL-1β、6-keto-PGF1α、TNF-α水平比较无差异，0期阳性和阳性士兵血清IL-1β、6-keto-PGF1α、TNF-α水平与训练前相比均明显升高(P<0.05)，0期阳性士兵血清IL-1β、6-keto-PGF1α、TNF-α值均明显低于本组和对照组阳性士兵(P<0.05)。结论：0期诊断技术预防军事训练所致新兵椎间盘源性下腰痛的效果明显，通过监测IL-1β、6-keto-PGF1α、TNF-α血清的水平变化也进一步证实0期诊断技术用于预防军事训练所致椎间盘源性下腰痛的可行性。 |
| 英文摘要: |
| ABSTRACT Objective: To assess the impact and effectiveness of zero-stage diagnostic technology on the serum concentration level of IL-1β, 6-keto-PGF1α and TNF-α in discogenic low back pain recruits Methods: Total of 596 recruits enrolled in 2015 were randomly selected from two military units, 306 of them were distributed to experiment group and the rest of 290 recruits to control group. Before they were enrolled into army, all the participants had received physical examinations and the results were recorded in a health file. During the time of military training, the zero-stage diagnostic technique were adopted to screen for discogenic low back pain in the experiment group on week 2nd, 4th, 6th 8th, 10th, 12th, respectively. And preventive measures were taken correspondingly. In the control group, discogenic low back pain was screened by the STANDARD published in 2002. All the positive cases detected by either the zero-stage diagnostic technique or the STANDARD received blood test for 6-keto-PGF1α、TNF-α and IL-1β. Results: The incidence of discogenic low back pain in experiment group (2.94 %) was much lower than that in control group (9.66 %)(x2=11.527, P<0.001) during the 12-week military training. On week 8th, 10th, 12th after the military training, the incidence of low back pain in experiment group was much lower than that in control group (P<0.05). No difference was found in the serum level of 6-keto-PGF1α, TNF-α and IL-1β between the two groups. But for the positive cases detected by either the zero-stage diagnostic technique or the STANDARD, the serum level increased significantly after the military training(P<0.05). The serum level of positive cases detected by the zero-stage diagnostic technique was significantly lower than that of the rest of the experiment group and the positive recruits detected by the STANDARD in the control group(P<0.05). Conclusion: The zero-stage technique for discogenic low back pain could effectively prevent the occurrence of discogenic low back pain. By means of monitoring the serum level change of IL-1β, 6-Keto-PGF1α and TNF-α, the zero-stage diagnostic technique was further proved as an effective and feasible method of preventing discogenic low back pain. |
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