| 李 菁,郑 英,陈小鹏,涂晶晶,万 婷.O型孕妇产前IgG血型抗体效价与新生儿溶血病的相关性[J].现代生物医学进展英文版,2017,17(9):1747-1749. |
| O型孕妇产前IgG血型抗体效价与新生儿溶血病的相关性 |
| The Correlation between the Titer of IgG Blood Group Antibody and Hemolytic Disease of Newborn in Type O Pregnant Women |
| Received:September 13, 2016 Revised:October 10, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.09.040 |
| 中文关键词: 抗体 新生儿溶血病 血型 产前 |
| 英文关键词: Antibody Hemolytic disease of newborn Blood type Prenatal |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨O型孕妇产前IgG血型抗体效价与新生儿溶血病（HDN）的相关性。方法：选择2013年1月至2015年12月期间，在我院分娩的夫妻ABO血型不合的O型Rh（D）阳性孕妇432例及新生儿为研究对象，观察孕妇血清IgG抗体效价情况，新生儿HDN发病情况，并分析二者相关性。结果：432例孕妇中血清IgG抗A（B）效价大于或等于1:64的有189例，占43.75%，随IgG抗A（B）效价升高，孕妇比例逐渐减少。随孕次增加，孕妇血清IgG抗A（B）效价逐渐增高，各组孕妇血清IgG抗A（B）效价比较有统计学差异（P<0.05）。随年龄增加，孕妇血清IgG抗A（B）效价逐渐增高，各组孕妇血清IgG抗A（B）效价比较有统计学差异（P<0.05）。随IgG抗A（B）效价升高，HDN发生率显著升高，各组比较有统计学差异（P<0.05）。等级相关检验显示，孕妇血清IgG抗A（B）与HDN发生呈正相关（r=0.732，P<0.05）。结论：O型孕妇产前IgG血型抗体是引起HDN的主要原因，其水平与HDN呈正相关，值得临床重视。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between the titer of IgG blood group antibody and hemolytic disease of new- born (HDN) in type O pregnant women. Methods: Selected 432 cases of type O Rh (D) positive pregnant women and neonate from Jan- uary 2013 to December 2015 in our hospital, maternal serum IgG antibody titer of observation, incidence of newborn HDN and analysis correlation. Results: In 432 cases of pregnant women, serum IgG anti A (B) titer is greater than or equal to 1:64 in 189 cases, accounting for 43.75%, with the IgG anti A (B) titer increased, the proportion of pregnant women gradually reduced. With the increase of pregnancy,pregnant women's serum A anti IgG A (B) titer gradually increased, the serum levels of IgG anti A (B) in each group was statistically sig- nificant difference (P<0.05). With the increase of age,pregnant women's serum A anti IgG A (B) gradually increased, the serum levels of IgG anti A (B) in each group was statistically significant difference (P<0.05). IgG (A) (B) titer increased, the incidence of HDN was sig- nificantly higher, there were statistically significant differences in each group (P<0.05). The grade correlation test showed that A (B) in the serum of pregnant women was positively correlated with HDN (r=0.732, P<0.05). Conclusion: The main cause of neonatal hemolytic disease is the O blood group antibody of IgG type pregnant women,which is positively correlated with the hemolytic disease of the new- born, which is worthy of clinical attention. |
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