| 李明丽,刘 灵,黄 伟,刘彦歧,夏明月.85例重症支原体肺炎患儿肺功能动态观察及临床意义[J].现代生物医学进展英文版,2017,17(9):1722-1725. |
| 85例重症支原体肺炎患儿肺功能动态观察及临床意义 |
| Dynamic Observation and Clinical Significance of Pulmonary Function in 85 Cases with Severe Mycoplasma Pneumoniae Pneumonia |
| Received:December 14, 2016 Revised:December 29, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.09.033 |
| 中文关键词: 重症支原体肺炎 肺功能 动态观察 |
| 英文关键词: Severe mycoplasma pneumonia Pulmonary function Dynamic observation |
| 基金项目:秦皇岛市科技项目(2011J059) |
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| 中文摘要: |
| 摘要 目的：分析85例小儿重症支原体肺炎(Mycoplasma pneumoniae pneumonia，MPP)肺功能指标动态变化情况，为临床上重症MPP的诊断和预后评估提供有效参考。方法：回顾性选取我院儿科接诊的重症MPP患儿85例为重症组，并选取基线资料差异不显著的轻症MPP患儿72例(轻症组)为研究对象。全部MPP患儿均行大环内酯类抗感染治疗，联合头孢曲松抗菌治疗，并予氨溴索祛痰等对症支持治疗，比较重症组与轻症组发病急性期与恢复期肺功能指标的变化。结果：①重症组在急性期大气道通气指标FVC、PEF、FEV1、FEV1/FVC表达量均显著低于轻症组（P＜0.05)；重症组FVC、PEF、FEV1、FEV1/FVC在恢复期和轻症组无显著差异（P＞0.05）；②重症组小气道通气指标FEF25、FEF50、FEF75、FEF25-75在各个时间节点均与轻症组有显著差异（P＜0.05）。结论：儿童重症MPP具有发病急性期大、小气道受损严重的特点，大气道在恢复期各项指标均接近正常，而小气道在恢复期各项指标仍处于异常表达的状态。肺功能指标的动态监测对重症MPP有一定临床意义。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the dynamic changes of pulmonary function in 85 cases with mycoplasma pneumoniae pneumo- nia (MPP), and provide effective reference for the diagnosis and prognosis of severe MPP. Methods: 85 children with severe MPP who were treated in our hospital were retrospectively chosen as severe group. 72 patients with mild MPP with insignificant differences in baseline data were selected as mild group. All MMP patients received anti-inflammatory therapy with Macrolides, anti-biotic therapy with ceftriaxone and symptomatic and supportive treatment with ambroxol. The pulmonary function changes of two groups in acute and recovery stages were compared. Results: ① The expression levels of major airway ventilation indicators FVC, PEF, FEV1, FEV1 / FVC during acute stage in severe group were significantly lower than those in the mild group (P<0.05). There was no significant difference in small airway ventilation indictors FVC, PEF, FEV1, FEV1 / FVC during recovery stage between two groups (P>0.05).②The FEF25, FEF50, FEF75 and FEF25-75 levels in the severe group were significantly different from those in the mild group at all time points (P<0.05). Conclusion: Severe MPP in children is characterized by serious damage of major and small airways during acute stage. Ventilation indicators of major airway turn approximately normal during recovery stage, while those of small airway still remain abnormal during this period. Dynamic monitoring of pulmonary function indicators has some clinical significance to severe MPP. |
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