| 王建宇,王伯良,田小溪,任 彬,袁 福.神经节苷脂联合高压氧对重度脑外伤急性期患者凝血功能的影响及促醒作用[J].现代生物医学进展英文版,2017,17(9):1674-1677. |
| 神经节苷脂联合高压氧对重度脑外伤急性期患者凝血功能的影响及促醒作用 |
| Effect of Ganglioside combined with Hyperbaric Oxygen on the Blood Coagulation Function and Recovery of Consciousness in Patients with Acute Severe Brain Trauma |
| Received:October 17, 2016 Revised:October 30, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.09.019 |
| 中文关键词: 度脑外伤急性期 神经节苷脂 高压氧 凝血功能 促醒作用 |
| 英文关键词: Acute severe brain trauma Ganglioside Hyperbaric oxygen Blood coagulation function Recovery of consciousness |
| 基金项目:陕西省自然科学基金项目(2005SM79) |
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| 中文摘要: |
| 摘要 目的：分析神经节苷脂联合高压氧对重度脑外伤急性期患者凝血功能的影响及促醒作用。方法：收集我院2014年2月至2015年2月收治的重度脑外伤急性期患者120例，对照组60例行常规治疗，研究组60例在常规治疗基础上联合神经节苷脂及高压氧治疗，比较两组治疗后内皮功能、凝血功能、Barthel指数及格拉斯哥加昏迷量表(GCS)评分变化，清醒时间、并发症及预后情况。结果：治疗后，研究组内皮功能明显优于对照组，D-二聚体(D-D)、凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)低于对照组，Barthel生活指数及GCS评分高于对照组，清醒时间短于对照组，并发症率低于对照组，预后良好率高于对照组，差异均具有统计学意义(P<0.05)。结论：神经节苷脂联合高压氧可有效改善重度脑外伤急性期患者的凝血功能，促进患者苏醒，改善患者的预后。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze of the effect of ganglioside combined with hyperbaric oxygen on the blood coagulation function and recovery of consciousness in patients with acute severe brain trauma. Methods: 120 patients with acute severe brain trauma were col- lected from February 2014 to February 2015, 60 cases in the control group were given routine treatment, 60 cases in the group were given ganglioside and hyperbaric oxygen treatment on the basis of control group, the endothelial function, blood coagulation function, Barthel index and Glasgow coma scale (GCS) changes, waking time, complications and prognosis were compared between the two groups after treatment. Results: After treatment, compared with the control group, the endothelial function was better, the D-dimer (D-D), prothrom- bin time (PT), activated partial prothrombin time (APTT) were lower than those of the control group, and the test life Barthel index and GCS score were higher, and the test waking hours was shorter than the control group, and the complication rate was lower than the con- trol group, and the good prognosis rate was higher than that of control group, and the differences were statistically significant (P<0.05). Conclusion: Ganglioside and hyperbaric oxygen could effectively enhance the blood coagulation function in patients with acute severe brain trauma, promote the patients to regain consciousness and improve the prognosis. |
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