| 宫满成,董文静,李淼沅,袁润强,丘少鹏.盐酸达泊西汀联合他达拉非治疗原发性早泄的临床研究[J].现代生物医学进展英文版,2017,17(9):1648-1650. |
| 盐酸达泊西汀联合他达拉非治疗原发性早泄的临床研究 |
| Clinical Efficacy of Dapoxetine Hydrochloride Combined with Tadalafil in the Treatment of Primary Premature Ejaculation |
| Received:October 21, 2016 Revised:November 19, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.09.012 |
| 中文关键词: 原发性早泄 盐酸达泊西汀 他达拉非 |
| 英文关键词: Primary premature ejaculation Dapoxetine hydrochloride Tadalafil |
| 基金项目:广东省医学科研基金项目(A2016058)；中山市科技计划项目(2015B1012)；中山市医学科研基金项目(2016J040) |
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| 中文摘要: |
| 摘要 目的：探讨盐酸达泊西汀联合他达拉非治疗原发性早泄的疗效。方法：将100例患者随机分成治疗组和对照组，每组50例。治疗组口服他达拉非片5 mg，每天1次，性交前按需口服盐酸达泊西汀片30 mg。对照组只按需口服盐酸达泊西汀片30 mg。疗程2个月。治疗期间嘱患者进行规律的性生活，每周1-2次，并做好相关记录。治疗前后行阴道内射精潜伏期（intravaginal ejaculation latency，IELT）IELT测评、患者及配偶性生活满意度评分。结果：与治疗前相比，两组治疗后IELT、 患者及配偶满意度均有明显改善，差异具有统计学意义(P<0.05)。而且治疗后治疗组与对照组比较，治疗组的IELT、患者及配偶满意度改善更为明显，差异亦具有统计学意义(P<0.05)。常见不良反应有颜面潮红、头晕、鼻塞，无需特殊处理，症状均自行缓解。结论：盐酸达泊西汀联合他达拉非治疗原发性早泄安全有效。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of dapoxetine hydrochloride combined with tadalafil for the treatment of primary pre- mature ejaculation. Methods: One hundred patients were randomly divided into treatment group and control group, 50 cases in each group. The treatment group was given oral tadalafil 5 mg, once a day, and on-demand oral 30 mg dapoxetine hydrochloride before sexual intercourse. The control group was treated with only on-demand oral 30 mg dapoxetine hydrochloride, lasting for 2 months. The patients during treatment were instructed for regular sex, 1-2 times a week, and the relevant records were kept. The IELT, the sexual satisfaction score of the patients and their spouse before and after the treatment was evaluated. Results: Compared with before treatment, the intrav- aginal ejaculation latency (IELT) IELT, and the sexual satisfaction of the patients and their spouses was improved significantly after treat- ment in two groups (P<0.05). When the treatment group compared with control group, the improvements of IELT, patient and spouse sat- isfaction of treatment group were more apparent after treatment. And the differences were statistically significant (P<0.05). The common adverse reactions included facial blushing, dizziness, nasal congestion, and these symptoms could be relieved by no special treatment. Conclusion: The treatment of dapoxetine hydrochloride combined with tadalafil is safe and effective for primary premature ejaculation. |
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