| 宋巧娟,奚耕思,贾艺舒,刘慧婷,程洪琴.多巴脱羧酶及其与神经类疾病的关联性研究进展[J].现代生物医学进展英文版,2017,17(8):1595-1600. |
| 多巴脱羧酶及其与神经类疾病的关联性研究进展 |
| Research Progress of Dopa Decarboxylase and Its Correlation with Neurological Diseases |
| Received:July 30, 2015 Revised:August 28, 2015 |
| DOI：10.13241/j.cnki.pmb.2017.08.051 |
| 中文关键词: 多巴脱羧酶 多巴胺 五羟色胺 神经类疾病 攻击行为 |
| 英文关键词: Dopa decarboxylase Dopamine Serotonin Neurological diseases Aggressive behaviour |
| 基金项目:国家级精品视频公开课项目（994230） |
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| 中文摘要: |
| 摘要：多巴脱羧酶（dopa decarboxylase, DDC）又称作芳香族L-氨基酸脱羧酶，是儿茶酚胺生物合成途径中重要的酶之一，具有多种生物学功能。多巴脱羧酶可分别催化L-3,4-二羟基苯丙氨酸（L-多巴）和L-5-羟色氨酸合成两种神经递质多巴胺和五羟色胺。多巴胺和五羟色胺在脊椎动物和无脊椎动物的生殖、发育、行为和免疫应答过程中均具有重要作用。此外，它还与多种神经类疾病和社会行为有关。多巴脱羧酶一般以二聚体的形式存在于哺乳类和昆虫的多种神经和非神经组织中。本文从多巴脱羧酶的结构、催化机制、与神经类疾病及其攻击性社会行为的关联性研究进展等方面进行了综述。 |
| 英文摘要: |
| ABSTRACT: Dopa decarboxylase (DDC), as aromatic L-amino acid decarboxylase, belongs to one of the important enzymes in the catecholamine biosynthesis pathway, which possesses variety biological functions. DDC can catalyze L-3, 4-dihydroxy phenylalanine (L-dopa) and L-5-hydroxy tryptophan to synthesis dopamine and serotonin respectively. Dopamine and serotonin as two neurotransmitters play an important role in reproduction, development, behavior, and the immune response process in vertebrates and invertebrates. In addition, DDC is associated with various neurological disease and social behaviors such as aggression behavior. Dopa decarboxylase generally exists in nerve and non-nerve tissues of mammals and insects in the form of dimers. In this paper, we mainly review DDC structure, catalytic mechanism and functions, beside that, the research progress on the correlation of DDC with neurological diseases, social aggressive behaviou has also been involved. |
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