| 彭 鹏,邹文蓉,王 瑜,赵清梅,白洋禄.恶性淋巴瘤患者血清CEA，CA125，LDH及β2-MG水平变化与肿瘤临床分期和预后的关系[J].现代生物医学进展英文版,2017,17(8):1483-1486. |
| 恶性淋巴瘤患者血清CEA，CA125，LDH及β2-MG水平变化与肿瘤临床分期和预后的关系 |
| Relationships of Serum CEA, CA125, LDH and β2-MG in Patients with Malignant Lymphoma and the Clinical Stage and Prognosis |
| Received:October 13, 2016 Revised:October 27, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.08.020 |
| 中文关键词: 恶性淋巴瘤 肿瘤标志物 化疗 放疗 疗效 |
| 英文关键词: Malignant lymphoma Tumor marker Chemotherapy Radiotherapy Curative effect |
| 基金项目:绵阳市卫生局基金项目（120169） |
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| 中文摘要: |
| 摘要 目的：探讨恶性淋巴瘤患者血清CEA、CA125、LDH、β2-MG水平及其与临床分期和预后的关系。方法：选择2014年1月-2016年1月我院血液内科收治的86例ML患者纳入观察组，选择同期健康体检者50例纳入对照组，比较两组研究对象血清CEA、CA125、LDH、β2-MG水平；同时比较不同临床分期及治疗效果的ML其血清CEA、CA125、LDH、β2-MG水平的差异。结果：观察组血清CEA、CA125、LDH、β2-MG水平均明显高于对照组，差异均有统计学意义（P＜0.05）；临床分期为Ⅲ-Ⅳ期的ML患者其血清CEA、CA125、LDH、β2-MG水平明显高于临床分期为Ⅰ-Ⅱ期者，差异有统计学意义（P＜0.05）；本研究86例患者中有68例患者为治疗有效纳入有效组，18例患者治疗无效纳入无效组；有效组患者治疗后血清CEA、CA125、LDH、β2-MG水平较治疗前明显下降，且低于无效组，差异均有统计学意义（P＜0.05）。结论：血清CEA、CA125、LDH、β2-MG水平在ML患者可明显增高，且监测其水平变化对ML患者临床分期及近期疗效的判断具有重要意义。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the serum concentration of CEA, CA125, LDH, β2-MG in patients with malignant lymphoma (ML) and its relationship with clinical stage and prognosis. Methods: 86 cases of ML patients treated in Hematology Department of Our hospital from January 2014 to January 2016 were included into the observation group, and 50 healthy subjects were included into the control group. The concentration of serum CEA, CA125, LDH, β2-MG were compared in the two groups. The concentration of serum CEA, CA125, LDH and β2-MG in ML patients with different clinical stages and therapeutic effects were compared. Results: The serum concentration of CEA, CA125, LDH, β2-MG in the observation group were significantly higher than those in the control group (P<0.05). The serum concentration of CEA, CA125 , LDH, β2-MG in the patients with stage Ⅲ-Ⅳ were higher than that of Ⅰ-Ⅱ, the difference was statistically significant (P <0.05). In this study, 68 patients were included into the effective group and 18 patients in the ineffective group. The concentration of serum CEA, CA125, LDH and β2-MG in the effective group were significantly lower than before treatment and those in the ineffective group (P<0.05). Conclusion: Serum CEA, CA125, LDH, β2-MG concentration in patients with ML can be significantly increased, and its monitoring of concentration in ML is of great significance in clinical stage and short-term efficacy judgment. |
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