| 赖爱云,徐 健,梁 维,冯大莺,蒋少泉.阿达木单抗注射液联合白芍总苷治疗甲氨蝶呤不耐受型类风湿关节炎的临床疗效[J].现代生物医学进展英文版,2017,17(8):1474-1476. |
| 阿达木单抗注射液联合白芍总苷治疗甲氨蝶呤不耐受型类风湿关节炎的临床疗效 |
| Clinical Effect of Total Glucosides of Paeony and Adalimumab Solution Injection in Treatment of Rheumatoid Arthritis with Anti Rheumatoid Drug |
| Received:October 14, 2016 Revised:October 28, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.08.017 |
| 中文关键词: 阿达木单抗注射液 白芍总苷 类风湿关节炎 |
| 英文关键词: Adalimumab solution injection Total glucosides of paeony Rheumatoid arthritis |
| 基金项目:云南省科技厅自然科学基金项目(2006XFX02) |
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| 中文摘要: |
| 摘要 目的：探讨阿达木单抗注射液联合白芍总苷治疗甲氨蝶呤不耐受风湿关节炎患者的临床疗效。方法：收集我院治疗的86例甲氨蝶呤不耐受的类风湿关节炎患者，随机分为实验组和对照组，每组43例。对照组患者给予阿达木单抗注射液治疗，实验组患者在对照组基础上给予白芍总苷胶囊治疗。观察并比较两组患者的晨僵时间、血沉（ESR）、类风湿因子（FR）以及临床疗效进行检测并比较。结果：与治疗前相比，治疗后两组患者的晨僵时间、血沉（ESR）、类风湿因子（FR）水平均下降（P<0.05）；与对照组相比，实验组患者的晨僵时间、血沉（ESR）、类风湿因子（FR）水平较低（P<0.05），临床治疗有效率较高（P<0.05）。结论：阿达木单抗注射液联合白芍总苷能够降低甲氨蝶呤不耐受的类风湿关节炎患者的ESR、FR水平，改善患者的临床症状，临床疗效较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect of total glucosides of paeony combined with adalimumab injection on the treatment of rheumatoid arthritis with anti rheumatoid drug. Methods: 86 cases with rheumatoid arthritis who were treated in our hospital were selected and randomly divided into the experiment group and the control group, with 43 cases in each group. The patients in the control group were treated with adalimumab injection, and the patients in the experiment group were treated with total glucosides of paeony capsules on the basis of the control group. Then the morning stiffness time, erythrocyte sedimentation rate (ESR), rheumatoid factor (FR) and clinical curative effect of patients in the two groups were observed and compared. Results: Compared with before treatment, the morning stiffness time, erythrocyte sedimentation rate (ESR) and rheumatoid factor (FR) levels in the two groups decreased (P < 0.05); compared with the control group after treatment, the morning stiffness time, erythrocyte sedimentation rate (ESR) and rheumatoid factor (FR) level in the experiment group were lower (P<0.05), while the the clinical effective rate was higher (P<0.05). Conclusion: Total Glucosides of paeony combined adalimumab injection can reduce invalid antirheumatic drugs for rheumatoid arthritis patients of ESR, FR levels and improve the clinical symptoms, and the clinical curative effect is better. |
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