| 李克良,耿瑞慧,朱立勋,孙晓静,陆学胜.影响阿替普酶治疗急性缺血性卒中早期疗效的临床研究[J].现代生物医学进展英文版,2017,17(8):1464-1467. |
| 影响阿替普酶治疗急性缺血性卒中早期疗效的临床研究 |
| Clinical Studies on Influence of Efficacy of Alteplase in Early Treatment of Acute Ischemic Stroke |
| Received:June 29, 2016 Revised:July 25, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.08.014 |
| 中文关键词: 急性缺血性脑卒中 阿替普酶静脉 溶栓 预后 |
| 英文关键词: Acute ischemic stroke Alteplase Thrombolysis Prognosis |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨影响阿替普酶静脉溶栓治疗急性缺血性卒中早期疗效的因素。方法：回顾性分析2010年11月至2014年11月我院接受阿替普酶静脉（rt-PA）溶栓治疗的49例急性缺血性卒中患者的临床数据，根据美国国立卫生研究院神经功能缺损评分(NIHSS评分)，溶栓后24h评分减少超过3分为溶栓早期有效组（24例），否则为溶栓早期无效组（25例），比较两组各临床数据的差异。结果：两组患者性别、年龄、吸烟史、酗酒史、高血压病史、糖尿病史、溶栓前血糖、血生化、血压等均无差异（P＞0.05）；早期有效组患者房颤发生率、脑白质病变发生率和溶栓前NIHSS评分较早期无效组低，差异均有统计学意义（P＜0.05）；早期有效组患者90天生活自理率较早期无效组高，差异有统计学意义（P＜0.05）。结论：阿替普酶静脉溶栓后早期疗效好者3个月预后好；溶栓前无房颤、无白质疏松患者溶栓后早期疗效好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate factors of the early curative effect of intravenous thrombolysis for acute ischemic stroke by alteplase. Methods: The clinical data of 49 cases of acute ischemic stroke patients accepted therapy of alteplase intravenous thrombolysis from November 2010 to November 2014 in our hospital were retrospectively analysis, according to the national institutes of health stroke scale(NIHSS score), 24 h after thrombolysis score less than 3 was divided into early effective group(24 cases), or invalid for early thrombolysis group (25 cases), the difference of the clinical data between two groups were compared. Results: gender, age, smoking history, history of alcoholism, history of hypertension, diabetes, blood glucose, blood biochemistry, blood pressure Before thrombolysis and so on between two groups had no difference (P>0.05); Incidence of atrial fibrillation in patients with early effective group, the incidence of cerebral white matter lesions and thrombolysis before NIHSS score was lower than those of early invalid group, the difference had statistical significance (P<0.05); 90-day care of patients with early effective group rate earlier invalid group was higher,the difference was statistically significant (P<0.05). Conclusion: Prognosis of early curative effect after intravenous thrombolysis enzyme prognostic variables in 3 months is good, early curative effect of Before thrombolysis loose after thrombolysis in patients with atrial fibrillation,white matter is good. |
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