| 李明丽 刘灵△ 黄伟 任高伟 夏明月.肺泡灌洗技术对重症支原体肺炎患儿血清炎症因子及肺功能的影响[J].现代生物医学进展英文版,2017,17(7):1353-1356. |
| 肺泡灌洗技术对重症支原体肺炎患儿血清炎症因子及肺功能的影响 |
| Effects of Bronchoalveolar Lavage on SerumLevels of Inflammatory Factorsand Pulmonary Functions in Children with Severe Mycoplasma Pneumonia |
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| DOI： |
| 中文关键词: 肺泡灌洗技术 重症支原体肺炎 炎症 肺功能 |
| 英文关键词: Bronchoalveolar lavage Severe mycoplasma pneumonia Inflammation Pulmonary function |
| 基金项目:秦皇岛市科技项目(2011J059) |
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| 中文摘要: |
| 目的：探讨支气管肺泡灌洗液（Bronchoalveolar Lavage Fluid，BALF）技术应用于儿科重症支原体肺炎（Severe Mycoplasma
Pneumoniae Pneumonia，SMPP）对患儿的血清炎症因子表达影响及肺功能的变化，旨在为临床上SMPP的诊治提供科学参考。方
法：回顾性选取我院收治的SMPP 患儿83例，按照治疗方式不同，分为两组，对照组41例，静滴阿奇霉素，研究组42 例，采用静
滴阿奇霉素3-5 天行BALF灌洗生理盐水+布地奈德治疗。于治疗7 d后对比两组治疗前后及组间肺功能和炎症指标的变化。结
果：研究组IL-2、IL-6、IL-10表达水平均较对照组显著降低，差异有统计学差异(P＜0.05)；研究组mPAP 、PAWP、PVR均比对照组
下降明显，差异有显著性意义(P＜0.05)。结论：BALF技术可明显改善患儿炎症因子表达，对促进患儿肺功能恢复正常有良好作
用，适用于儿童SMPP 的治疗。 |
| 英文摘要: |
| Objective:To investigate the effect of Bronchoalveolar Lavage Fluid (BALF) on the expression of inflammatory cytokines
and the changes of pulmonary function in children with severe mycoplasma pneumoniae (SMPP), so as to provide scientific references
for the clinical diagnosis and treatment of SMPP.Methods:83 patients with SMPP admitted in our hospital were retrospectively
chosen. According to different treatment methods, they were divided into two groups. 41 patients in the control group were treated with
azithromycin. 42 patients in the study group were taken with BALF lavage azithromycin treatment. The changes of pulmonary function
and inflammation index were compared between the two groups before and after treatment.Results:The levels of IL-2, IL-6 and IL-10 in
study group were significantly lower than those in control group (P<0.05). The mPAP, PAWP and PVR in the study group were significantly
lower than those in the control group (P<0.05).Conclusion:BALF can significantly improve the expression of inflammatory factors
in children, and has good effect on promoting the recovery of normal lung function in children, and it is suitable for the treatment of
SMPP in children. |
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