| Objective:To investigate the significance of serumliver fibrosis in patients with hepatitisBin clinical research.Methods:136 cases of hepatitis B patients admitted to our hospital were divided into 3 groups according to the degree of mild, moderate, severe,
mild group, moderate group and severe group, 42 cases in each group. All patients were observed and compared with HBV markers,
HBV-DNA levels, hyaluronic acid (HA), serumtype III collagen peptide (PCIII), type IV collagen (CIV) and laminin (LN) levels.Results:HBV-DNA levels in three groups of patients was gradually increased, compared with that of the mild group, moderate group and severe
group and the HBV-DNA level are higher, and compared with moderate group patients, severe group patients HBV-DNA level is higher,
the difference is statistically significant (P<0.05). Compared with the mild group, moderate group and severe group patients HA, PCIII,
civ and LN levels are higher, and compared with moderate group patients, patients in the severe group ha, PCIII level is higher, the difference
is statistically significant (P<0.05); HBV-DNA level was positively correlated with the HA, PCIII, CIV and LN levels.Conclusion:The serological detection indexes of hepatitis B patients and serum liver fibrosis were determined, which could be used to evaluate the
progress of hepatitis B fibrosis process. |
