| 黄俊 向徳森 付晓 陈瀑 罗鹏 邹麟.复方鳖甲软肝片联合阿德福韦酯对乙肝肝硬化患者肝功能和乙肝血清标
志物水平的影响[J].现代生物医学进展英文版,2017,17(7):1335-1338. |
| 复方鳖甲软肝片联合阿德福韦酯对乙肝肝硬化患者肝功能和乙肝血清标
志物水平的影响 |
| Effects of Fufang Biejia Ruangan Tablets Combined with Adefovir Dipivoxilon the Levels of Hepatitis B SerumMarkers of Patients with Hepatitis B LiverCirrhosis |
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| DOI： |
| 中文关键词: 复方鳖甲软肝片 阿德福韦酯 乙肝肝硬化 乙肝血清标志物 |
| 英文关键词: Fufang biejia ruangan tablets Adefovir dipivoxil Hepatitis B liver cirrhosis Hepatitis B serummarker |
| 基金项目:重庆市自然科学基金项目(2008BB3068) |
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| 中文摘要: |
| 目的：探讨复方鳖甲软肝片联合阿德福韦酯对乙肝肝硬化患者肝功能和乙肝血清标志物水平的影响。方法：选择我院进行
治疗的乙肝肝硬化患者60 例，随机分为实验组与对照组，每组30例。对照组患者给予阿德福韦酯治疗，实验组患者在对照组基
础上给予复方鳖甲软肝片治疗。比较治疗前后两组患者血浆白蛋白(ALB)、丙氨酸氨基转移酶(ALT)、血清总胆红素(TBIL)及凝血
酶源时间(PT)水平、不良反应、HBeAg转阴率、HBV-DNA转阴率及HBeAg血清转化率。结果：与治疗前相比，两组患者治疗后的
血清ALB水平均升高，血清ALT、TBIL 及PT 水平均降低(P＜0.05)；与对照组相比，实验组患者的血清ALB 水平、HBeAg 转阴
率、HBV-DNA转阴率及HBeAg 血清转化率较高，血清ALT、TBIL、PT 水平、不良反应发生率较低(P＜0.05)。结论：复方鳖甲软肝
片联合阿德福韦酯较单用阿德福韦酯可更有效改善乙肝肝硬化患者的肝功能，并抑制病毒的复制，且安全性较高。 |
| 英文摘要: |
| Objective:To investigate the effects of fufang biejia ruangan tablets combined with adefovir dipivoxil on the levels of
hepatitis B serummarkers in patients with hepatitis B liver cirrhosis.Methods:60 patients with hepatitis B liver cirrhosis who were treated
in our hospital were selected and randomly divided into the experiment group and the control group, with 30 cases in each group. The patients
in the control group were treated with adefovirdipivoxil, and the patients in the experiment group were treated with Fufang biejia
ruangan tablets on the basis of the control group. Then the serum levels of albumin (ALB), alanine aminotransferase (ALT), total bilirubin
(TBIL) and the thrombin time (PT), incidence of adverse reactions, the HBeAg negative rate, HBV-DNA negative rate and HBeAg
serum conversion rate of patients in the two groups were observed and compared after treatment.Results:Compared with before treatment,
the serum levels of ALB in both groups were increased after the treatment, while the levels of ALT, TBIL and PT were decreased
(P<0.05). Compared with the control group after the treatment, the serumlevel of ALB in the experiment group was higher, while the levels
of ALT, TBIL and PT were lower (P<0.05); Compared with the control group, the incidence of adverse reactions and the HBeAg negative
rate, HBV-DNA negative rate and HBeAg serum conversion rate of experiment group were lower (P<0.05).Conclusion:Fufang
biejia ruangan tablets combine with Adefovir dipivoxil in the treatment of patients with hepatitis B liver cirrhosis had good clinical efficacy,
which was worthy of clinical application. |
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