| 吴育美 李继昌 刘海霞 陈莹 薛挺.乌司他丁治疗急性胰腺炎的临床疗效及对患者血清炎性因子水平的影响[J].现代生物医学进展英文版,2017,17(7):1331-1334. |
| 乌司他丁治疗急性胰腺炎的临床疗效及对患者血清炎性因子水平的影响 |
| Effect of Ulinastatin on Acute Pancreatitis and SerumLevels of InflammatoryFactors in Patients |
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| DOI： |
| 中文关键词: 乌司他丁 急性胰腺炎 IL-1 IL-6 CRP TNF-alpha |
| 英文关键词: UTI Acute pancreatitis IL-1 IL-6 CRP TNF-alpha |
| 基金项目: |
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| 中文摘要: |
| 目的：观察乌司他丁在急性胰腺炎临床治疗中的作用效果，分析其临床治疗价值。方法：选取我院治疗的急性胰腺炎患者
178 例，根据治疗方法不同分为观察组和对照组，每组89 例。对照组患者采用奥曲肽治疗，观察组患者采用乌司他丁与奥曲肽联
合治疗。观察并比较治疗前后患者APACHEⅡ评分和血清炎症因子变化及临床疗效。结果：入院时，两组血清CRP、IL-1、IL-6、
TNF-alpha、APACHEⅡ评分无统计差异(P>0.05)，治疗后，组内CRP、IL-1、IL-6、TNF-琢、APACHEⅡ评分明显下降(P＜0.05)；观察组
CRP、IL-1、IL-6、TNF-alpha、APACHEⅡ评分显著低于参照组(P＜0.05)；观察组临床总有效率(86.52%)显著高于参照组(71.91%)，观察
组并发症(12.36%)明显低于参照组(24.72%)，P<0.05，组间有统计差异。结论：乌司他丁能够显著提升急性胰腺炎的临床疗效，促进
患者康复，其作用机制可能与抑制炎症因子表达有关。 |
| 英文摘要: |
| Objective:To observe the clinical effect of ulinastatin on acute pancreatitis and the serum levels of inflammatory factors
in patients.Methods:178 cases with acute pancreatitis who were treated in our hospital were selected and according to the different
treatment methods, the patients were divided into the observation group and the control group, with 89 cases in each group. The patients
in the observation group were treated with UTI and octreotide, while the patients in the control group were treated with octreotide. Then
the changes of APACHEⅡ score and serum inflammatory factors of patients were observed and compared before and after treatment.
Results:At admission, the levels of serumCRP, IL-1, IL-6, TNF-alpha and APACHEⅡ score were without statistical differences (P> 0.05).After treatment, the CRP, IL-1, IL-6, TNF-alpha and APACHEⅡ score in the two groups significantly decreased (P<0.05). The CRP, IL-1,
IL-6, TNF-alpha and APACHEⅡ scores in the observation group were significantly lower than those of the control group (P <0.05). The total
clinical efficiency rate of the observation group was 86.52%, which was significantly higher than 71.91 in the control group, and the
complications in the observation group was 12.36%, which was significantly lower than 24.72%in the control group, and the differences
were statistically significant (P<0.05).Conclusion:Ulinastatin can significantly improve the clinical efficacy of acute pancreatitis, and
promote the rehabilitation of patients, and its mechanismmay be related to inhibition of inflammatory cytokine expressions. |
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