| 熊慧丽 王毅 赵晓宏 周庆元 柳杨.大剂量胰岛素联合西格列汀对老年2 型糖尿病患者的疗效[J].现代生物医学进展英文版,2017,17(7):1308-1310. |
| 大剂量胰岛素联合西格列汀对老年2 型糖尿病患者的疗效 |
| Effects of High-dose Insulin Combined with Sitagliptin on Elderly Patientswith Type 2 Diabetes Mellitus |
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| DOI： |
| 中文关键词: 胰岛素 西格列汀 糖尿病 疗效 |
| 英文关键词: Insulin Sitagliptin Type 2 diabetes mellitus Curative effect |
| 基金项目: |
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| 中文摘要: |
| 目的：研究大剂量胰岛素联合西格列汀对老年2 型糖尿病患者的疗效。方法：选择2012 年1 月～2015 年12月在我院进行
诊治的老年2 型糖尿病患者82例，随机分为两组，观察组采用大剂量胰岛素联合西格列汀治疗，对照组采用大剂量胰岛素治疗，
两组均治疗3 个月。比较两组治疗前后的甘油三酯、总胆固醇、低密度脂蛋白和高密度脂蛋白水平，餐后2 h血糖、空腹血糖、糖化
血红蛋白，胰岛素抵抗指数、胰岛素分泌指数、每日胰岛素总量和低血糖发生次数。结果：对照组治疗前后的血脂水平无明显差异
（P>0.05），观察组治疗后的甘油三酯、总胆固醇和低密度脂蛋白明显降低（P<0.05），高密度脂蛋白明显升高（P<0.05）；治疗后，两
组的餐后2 h 血糖、空腹血糖、糖化血红蛋白均明显降低（P<0.05），且观察组降低更为明显（P<0.05）；对照组治疗前后的胰岛素抵
抗指数、胰岛素分泌指数和每日胰岛素总量均无明显差异(P>0.05)，观察组治疗后的胰岛素抵抗指数和每日胰岛素总量均明显降
低(P<0.05)，胰岛素分泌指数明显升高(P<0.05)；两组治疗前后低血糖发生次数和身体质量指数均无明显差异(P>0.05)。结论：大剂
量胰岛素联合西格列汀能有效控制老年2 型糖尿病患者的血糖水平，改善胰岛beta细胞功能，减少胰岛素用量，是一种安全有效的
治疗方法。 |
| 英文摘要: |
| Objective:To study the effects of high-dose insulin combined with sitagliptin on elderly patients with type 2 diabetes
mellitus.Methods:82 cases of elderly patients with type 2 diabetes mellituswho were treated in our hospital from January 2012 to December
2015 were selected and divided into two groups randomly, the patients in observation group were treated with high-dose insulin
combined with sitagliptin, and the patients in control group were treated with high-dose insulin. The triglyceride, total cholesterol,
low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels, postprandial 2 h blood glucose, fasting glucose, glycosylated
hemoglobin, insulin resistance, insulin secretion index, total daily insulin, and the frequency of hypoglycaemia of the two groups
were compared.Results:The lipid level before and after treatment had no significant difference between the two groups (P>0.05), after
treatment, the triglyceride, total cholesterol and low density lipoprotein of observation group was decreased significantly (P<0.05), the
level of high-density lipoprotein cholesterol was increased significantly (P<0.05); the postprandial 2 h blood glucose, fasting glucose, glycosylated
hemoglobin of two groups were significantly lower (P<0.05), and it was more significantly in observation group (P<0.05); the
insulin resistance, insulin secretion index and total daily insulin had no significant difference between the two groups(P>0.05), the insulin
resistance index and total daily insulin of observation group was decreased significantly (P<0.05), the insulin secretion index was increased
significantly (P<0.05); the frequency of hypoglycaemia and body mass index had no significant difference between two groups
before and after treatment (P>0.05).Conclusion:High-dose insulin combined with sitagliptin can effectively control the blood glucose
level of elderly patients with type 2 diabetes mellitus, improve islet beta-cell function, and reduce the dosage of insulin, which is safe and effective. |
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