| 陈维阳 丁一 习建东 唐德涛 李小依.STAT3, beta-catenin 在原发性肝细胞癌组织中的表达及其与临床病理参数的关系[J].现代生物医学进展英文版,2017,17(6):1142-1145. |
| STAT3, beta-catenin 在原发性肝细胞癌组织中的表达及其与临床病理参数的关系 |
| Expression of STAT3 and beta-catenin in Primary Hepatocellular Carcinomaand Their Clinical Significance |
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| DOI： |
| 中文关键词: 肝细胞癌 beta-catenin STAT3 免疫组织化学 |
| 英文关键词: Hepatocellular carcinoma beta-catenin STAT3 Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨信号转导子和转录激活子3（STAT3）及beta- 连环素蛋白（beta-catenin）在原发性肝细胞癌（HCC）中的表达及其与临床
病理特征的关系。方法：使用免疫组化SP两步法检测120例HCC、30 例癌旁肝组织、30例肝硬化组织及30 例肝血管瘤标本中正
常肝组织的STAT3 蛋白及beta-catenin的表达，分析STAT3 蛋白和beta-catenin 表达与HCC 临床病理特征的关系，并采用Spearman
等级相关分析法探讨HCC 组织中STAT3 蛋白与beta-catenin 的相关性。结果：STAT3 蛋白在HCC、癌旁组织、肝硬化组织、正常肝
组织中的阳性率分别为64.17%、13.33%、43.33％及0.00%，阳性表达主要位于细胞质，茁-catenin 在HCC、癌旁组织、肝硬化组织、
正常肝组织中的阳性率分别为62.50%、16.67%、33.33%及0.00%，阳性表达亦主要位于细胞质。STAT3 及beta-catenin 在上述各类组
织中阳性率，差异均具有显著性（P<0.05）。HCC中STAT3蛋白阳性率在不同年龄、肿瘤大小、甲胎蛋白（AFP）、病理分化程度及门
脉癌栓组间差异有统计学意义（P<0.05）。HCC 中STAT3 与beta-catenin 表达呈显著正相关（P<0.05）。结论：STAT3 及beta-catenin 在
HCC 的发生、发展中起着重要作用，且二者表达强度呈显著正相关。 |
| 英文摘要: |
| Objective:To explore the expression of signal transducer and activator of transcription 3(STAT3) and beta-catenin in the
primary hepatocellular carcinoma (HCC) and the relationship with the clinical pathological features of HCC.Methods:Immunohistochemical SP two-step methods was used to detect the expression of the STAT3 and beta-catenin in 120 cases of primary
hepatocellular carcinoma, 30 cases of paracarcinous liver tissue,30 cases of cirrhosis of liver, and 30 cases of normal liver tissue.In
addition, the relationship between expressions of STAT3, beta-catenin in HCC and the clinicpathologic characteristics was analyzed, and
the Spearman was used to explore the correlation of STAT3 and beta-catenin in HCC tissues.Results:The STAT3 were expressed in
cytoplasm. The positive expression rate of SATA 3 in HCC tissue, paracarcinous liver tissue, liver cirrhosis tissue and normal liver tissue
was 64.17%, 13.33%, 43.33%, and 0.00%, respectively. 茁-catenin was also expressed in cytoplasm, and the positive expressed rate of
茁-catenin in HCC tissue, paracarcinous liver tissue, liver cirrhosis tissue and normal liver tissue was 62.50%, 16.67%, 33.33%,and
0.00%, respectively. There were significant difference of positive rate of STAT3 and beta-catenin among these groups(P<0.05). The STAT3
expression in HCC was correlated with the age, size of tumor, Alpha fetal protein (AFP), differentiation degree, and vascular tumor
emboli(P<0.05). The expression of STAT3 and beta-catenin had significant positive correlation in HCC(P<0.05).Conclusion:The STAT3
and beta-catenin may play a critical role in the genesis and the development of HCC, and have a significant positive correlation. |
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