| 王小龙 刘兴 苏依图 张文谦 周敏 曹中伟.浆细胞性乳腺炎组织中IL-1beta及TNF-alpha的表达及临床意义[J].现代生物医学进展英文版,2017,17(6):1110-1112. |
| 浆细胞性乳腺炎组织中IL-1beta及TNF-alpha的表达及临床意义 |
| Expression of IL-1 beta and TNF-alpha in Tissues of Plasma Cell Mastitisand its Clinical Significance |
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| DOI： |
| 中文关键词: 浆细胞性乳腺炎 组织 炎性因子 表达 相关性 |
| 英文关键词: Plasma cell mastitis Tissue Inflammatory factor Expression Correlation |
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| 中文摘要: |
| 目的：研究浆细胞性乳腺炎（PCM）组织中白细胞介素-1beta（IL-1beta）及肿瘤坏死因子-alpha（TNF-alpha）的表达及其临床意义。方法：选
择2013 年11 月到2016 年4 月在内蒙古自治区人民医院就诊的PCM 患者50例作为观察组，选择上述观察组患者中距炎性肿
物边缘>3cm 且镜检为正常乳腺组织23例作为对照组，比较两组组织中IL-1beta及TNF-alpha的表达，分析不同临床分期和分型者
IL-1beta及TNF-alpha的表达及相关性。结果：观察组组织中的IL-1beta及TNF-alpha的表达水平均分别明显高于对照组，差异有统计学意义
（P<0.05）；观察组急性期及亚急性期的患者IL-1beta及TNF-alpha水平分别明显高于慢性期，且急性期明显高于亚急性期，差异均有统
计学意义（P<0.05）；不同临床分型者的IL-1茁及TNF-琢水平相比，差异均无统计学意义（P＞ 0.05）；依照PEARSON法分析相关性
发现，观察组不同临床分期患者的IL-1茁及TNF-琢呈正相关（r=0.860，P=0.000）。结论：PCM组织中的IL-1beta及TNF-alpha高表达，且
两者对PCM 的发展发挥了协同作用。 |
| 英文摘要: |
| Objective:To study the expression of IL-1beta and TNF- alpha in tissues of plasma cell mastitis (PCM) and its clinical
significance.Methods:50 cases of patients with PCM who were treated in the Inner Mongolia Autonomous Region People's Hospital
from November 2013 to April 2016 were selected as observation group, and selected 23 cases of normal breast tissues those>3 cm from
the edge of the inflammatory mass and checked by microscopic examination of the patients as control group. The expression of IL-1 and
TNF- in two groups were compared, and the expression and correlation of IL-1 and TNF- in different clinical stages and types were
analyzed.Results:Expression levels of IL-1茁and TNF-琢in tissues in observation group were significantly higher than those in the
control group, the difference was statistically significant (P<0.05). The levels of IL-1beta and TNF-alpha in patients with acute and subacute
stage were significantly higher than those in chronic phase, and the acute phase was significantly higher than that of subacute stage, the
difference was statistically significant(P<0.05). The difference of expressions levels of IL-1eta and TNF-alpha in different clinical classification
was not statistically significant in observation group (P>0.05). According to the PEARSON analysis, the the expression of IL-1beta and
TNF-alpha was positively correlated in patients with different clinical stages in observation group (r=0.860, P=0.000).Conclusion:The
expressions of IL-1beta and TNF-alphain PCMtissue is high,and they play a synergistic role on the development of PCM. |
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