| 王少鑫 崔立红 弓三东 李超 于兰 罗哲.西甲硅油联合枯草杆菌肠球菌对肠易激综合征的疗效观察[J].现代生物医学进展英文版,2017,17(6):1102-1105. |
| 西甲硅油联合枯草杆菌肠球菌对肠易激综合征的疗效观察 |
| Effect Observation of Simethicone Emulsion Combined with Bacillus Subtilisin Treatment of Irritable Bowel Syndrome |
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| DOI： |
| 中文关键词: 西甲硅油乳剂 枯草杆菌肠球菌二联活菌肠溶胶囊 疗效 肠易激综合征 |
| 英文关键词: Simethicone emulsion Treatment efficiency Irritable bowel syndrome |
| 基金项目:吴阶平临床科研专项资助基金项目（320.6750.13175）；海军后勤科研计划课题（CHJ12J027） |
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| 中文摘要: |
| 目的：探讨西甲硅油乳剂联合枯草杆菌肠球菌二联活菌肠溶胶囊（美常安）在肠易激综合征（IBS）治疗中的临床效果。方法：
将2014 年1 月至2015 年10 月收治的180 例IBS患者随机分为西甲硅油乳剂联合枯草杆菌肠球菌二联活菌治疗组92 例和单
药枯草杆菌肠球菌二联活菌治疗对照组88 例，治疗4 周后随访观察两组患者的治疗总有效率、不同胃肠症状的治疗有效率，以
及不同型IBS患者的胃肠症状评分。结果：IBS 治疗组的治疗总有效率为88.0 %，明显高于对照组70.5 %（P<0.05）。治疗4 周后腹
胀和排便次数改善的有效率分别为94.6 %和78.3 %明显高于对照组的77.3 %和60.2 %（P<0.05），但两组在腹痛和排便性状改善
方面比较无明显差异（P>0.05）。对两组不同胃肠症状评分结果显示，同组同型IBS 治疗4 周后胃肠症状评分均明显低于治疗前
（P<0.05），治疗有效。但两组同型IBS患者的治疗后胃肠症状评分比较时，仅在便秘型IBS 患者差异明显（P<0.05）。结论：西甲硅
油乳剂联合枯草杆菌二联活菌肠溶胶囊对肠易激综合征（IBS）患者治疗有效，对缓解腹胀和改善排便次数上治疗效果尤为明显，
对IBS 便秘型患者的胃肠症状恢复疗效最佳。 |
| 英文摘要: |
| Objective:To observe the clinical effect of simethicone emulsion combined with Bacillus subtilis in the treatment of
patients with irritable bowel syndrome (IBS).Methods:A total of 180 patients with IBS during January 2014 and October 2015 were
randomly divided into simethicone emulsion combined with Bacillus subtilis group (treatment group, n=92) and single Bacillus subtilis
group (control group, n=88). All patients were treated for 4 weeks and were followed up to observe the symptoms of gastrointestinal tract.
Then the total effective rate of treatment, the respective effective rate of different gastrointestinal symptoms and the Gastrointestinal
Symptom Rating Scale (GSRS) were analyzed in different types of IBS patients before and 4 weeks after the treatment.Results:The total
efficiency of patients in treatment group after 4 weeks of treatment was 88.0 %, significantly higher than that of the control group, the
total efficiency of 70.5% (P<0.05). The treatment efficiency of abdominal distension and stool frequency in treatment group were
respectively 94.6 % and 78.3 %, significantly higher than that of the control group of 77.3 % and 60.2% (P<0.05), but the abdominal
pain and stool characteristics change in two groups had no significant difference (P>0.05). GSRS of same type IBS patients in the same
group after 4 weeks of treatment were significantly lower than that of IBS patients before treatment (P<0.05), and the treatment was quite
effective. However, in four groups of patients with different types of IBS in 4 weeks after the treatment, only GSRS of patients with
IBS-constipation has significant difference (P<0.05).Conclusion:Simethicone emulsion combined with Bacillus subtilis is effective for
the patients with irritable bowel syndrome (IBS), which can particularly alleviate pain and improve the stool frequency, Gastrointestinal
symptomrecovery of the patients with constipation has the best effect among different type IBS patients. |
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