| 郭振丰,李天时,其力木格,周婉祎,李雪连.丝氨酸蛋白酶抑制剂PN-1的研究进展[J].现代生物医学进展英文版,2017,17(5):989-992. |
| 丝氨酸蛋白酶抑制剂PN-1的研究进展 |
| Study on Serine Protease Inhibitor PN-1 |
| Received:March 21, 2016 Revised:April 18, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.05.051 |
| 中文关键词: 蛋白连接酶-1 丝氨酸蛋白酶抑制剂 肿瘤 神经 肺部相关疾病 |
| 英文关键词: Protease nexin-1 Serine proteinase inhibitor Tumour Nervous system Lung related diseases |
| 基金项目:中国博士后科学基金第五批特别资助（2012T50355）；黑龙江省博士后科研启动基金项目（LBH-Q13112） |
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| 中文摘要: |
| 摘要：丝氨酸蛋白酶抑制剂PN-1，由SERPINE2基因编码，是丝氨酸蛋白酶抑制剂超家族中的一员，是由多种细胞分泌的单链糖蛋白。PN-1在血浆中表达很少，但在多种器官和细胞类型中均有发现，在许多生物事件中发挥着重要的调节作用。PN-1在血液凝结、免疫反应、纤溶、血管发生、炎症和肿瘤抑制等一系列生理病理过程中发挥着重要作用。近年来对PN-1的研究，日益受到人们的关注，本文将主要综述PN-1在循环系统、肿瘤、神经系统以及肺部相关疾病中的最新研究进展及作用。 |
| 英文摘要: |
| ABSTRACT: Serine protease inhibitor protease nexin-1 (PN-1) is encoded by the SERPINE2 gene.It belongs to a member of serine protease inhibitor superfamily, and is a kind of glycoprotein which is secreted by a variety of cells. PN-1 is a serpin that is barely de- tectable in the plasma but is discovered in many organs and cell types, which plays a key role in the physiological and pathological pro- cesses, such as the blood congealing, immunoreactions, plasmin fusion, inflammation and tumor suppressor. In recent years, the research of PN-1 has been paid more attention to. This article will summarize the latest research progress of PN-1 in the circulatory system, cancer, nervous system and lung-related diseases. |
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