| 杜双霞,张晓红,祖明立,王亚男,李 娜.血浆hs-CRP和Hcy水平与血管性痴呆患者认知功能的关系[J].现代生物医学进展英文版,2017,17(5):916-918. |
| 血浆hs-CRP和Hcy水平与血管性痴呆患者认知功能的关系 |
| Relationship between the Levels of Plasma Hcy and hs-CRP and Cognitive Function in Patients with Vascular Dementia |
| Received:July 15, 2016 Revised:August 12, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.05.030 |
| 中文关键词: 超敏C反应蛋白 血浆同型半胱氨酸 血管性痴呆 认知功能 |
| 英文关键词: Hypersensitive C-reactive protein Homocysteine Vascular dementia Cognitive function |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨血浆超敏C反应蛋白(hs-CRP)和同型半胱氨酸（Hcy）水平与血管性痴呆（VD）患者认知功能的相关性。方法：回顾性分析2011年12月-2014年7月间我院100例脑梗死住院患者的临床资料，按诊断结果，将患者分为VD 组55例和非VD组45 例，另选取同期50例健康体检者为对照组。检测并比较3组血浆hs-CRP和Hcy水平，采用简易精神状态速检表（MMSE）对VD组进行痴呆程度分类，分析其与血浆hs-CRP和Hcy的相关性。结果：血浆Hcy与hs-CRP在3组间差异有统计学意义（P<0.05），且VD组、非VD组均显著高于对照组，VD组显著高于非VD组，差异均有统计学意义（P<0.05）。随着痴呆程度的加重，MMSE评分逐渐降低，血浆hs-CRP与Hcy水平则逐渐升高，差异有统计学意义（P<0.05）。经相关性分析发现，MMSE评分和血浆hs-CRP与Hcy水平均呈负相关(r=-0.672,-0.703,P<0.05)。结论：血浆hs-CRP与Hcy水平与VD患者的认知功能负相关，临床加强对两指标的检测对VD的诊断及防治有着重要的临床意义。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation between the leves of plasma hypersensitive C-reactive protein(hs-CRP) and plasma homocysteine(Hcy) and cognitive function in patients with vascular dementia(VD). Methods: The clinical data of 100 cases of hospital- ized patients with cerebral infarction were retrospectively analyzed from December 2011 to July 2014, they were divided into VD groups 55 cases, and non-VD groups 45 cases according to diagnostic criteria, selected 50 cases of healthy persons in the same period as the con- trol group. Detected and compared plasma hs-CRP and Hcy levels in three groups, used mini mental state examination(MMSE) to classify the degree in VD group, and analyzed its correlation with plasma Hcy and hs-CRP. Results: Plasma Hcy and hs-CRP among 3 groups had significant difference(P<0.05), and non-VD and VD group were significantly higher than the control group, VD group was significantly higher than the non-VD group, which were significant differences(P<0.05). As the degree of dementia increased and the MMSE score de- creased and the plasma levels of plasma hs-CRP and Hcy levels were increased gradually, which was statistically significant difference(P<0.05). Correlation analysis found that the MMSE score negatively correlated with the plasma Hcy and hs-CRP (r=-0.672,-0.703, P<0.05). Conclusion: Plasma Hcy and hs-CRP are negatively correlated with cognitive function in patients with VD, detecting these two in- dexes is important significance for clinical diagnosis,prevention and treatment of VD. |
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