| 冯 卉,李志艳,张大鹍,冯 松,陈 敏,董晓宇,刘 阳.肝组织弥散度成像在慢性肝损伤诊断中的临床研究[J].现代生物医学进展英文版,2017,17(5):870-873. |
| 肝组织弥散度成像在慢性肝损伤诊断中的临床研究 |
| Clinical Study of Liver Tissue Dispersion Imaging in Diagnosis of Chronic Liver Injury |
| Received:September 19, 2016 Revised:September 30, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.05.017 |
| 中文关键词: 肝脏 纤维化 炎症 弹性 |
| 英文关键词: Liver Fibrosis Inflammation Elasticity |
| 基金项目:解放军302医院创新基金项目（YNKT2012033） |
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| 中文摘要: |
| 摘要 目的：探讨Strain Histogram组织弥散度成像技术在慢性肝损伤程度无创诊断中的临床价值。方法：应用Strain Histogram组织弥散度成像技术定量检测180例慢性肝炎（病毒性肝炎105例，非病毒性肝炎75例）患者肝脏弹性特征值，对照病理，分析肝脏弹性特征值与肝纤维化及肝脏炎症程度的相关性。结果：180例慢性肝炎患者LF指数用于判断轻度与中重度纤维化的诊断界值为2.785，LF指数越大，纤维化程度越重，灵敏度76.6%，特异度48.9%；LF指数用于判断轻度与中重度炎症的诊断界值为2.925，LF指数越大，炎症程度越重，灵敏度73.2%，特异度56.8%。105例病毒性肝炎患者LF指数用于判断轻度与中重度纤维化的诊断界值为2.975，LF指数越大，纤维化程度越重, 灵敏度69.2%，特异度67.1%；LF指数用于判断轻度与中重度炎症的诊断界值为2.915，LF指数越大，炎症程度越重, 灵敏度80.0%，特异度57.8%。75例非病毒性肝炎患者LF指数与肝纤维化和炎症程度不具有相关性。结论：LF指数可以反映肝脏纤维化及炎症程度，诊断灵敏度高，LF指数越大，肝纤维化及炎症程度越重。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical value of Histogram Strain tissue dispersion imaging in noninvasive diagnosis of chronic liver injury. Methods: Liver elasticity of 180 patients with chronic hepatitis (105 viral hepatitis and 75 non-viral hepatitis) was quantitatively detected by elastic imaging technique. The correlation between liver elasticity characteristic value and liver fibrosis and in- flammation degree were analyzed. Results: The LF diagnostic cut-off value in differentiating mild and moderate to severe fibrosis in 180 chronic hepatitis patients was 2.785, with a sensitivity of 76.6% and specificity 48.9%. The LF diagnostic cut-off value in differentiating mild and moderate to severe inflammation in 180 chronic hepatitis patients was 2.925, with a sensitivity of 73.2% and specificity 56.8%. The LF diagnostic cut-off value in differentiating mild and moderate to severe fibrosis in 105 viral hepatitis patients was 2.975, with a sensitivity of 69.2% and specificity 67.1%. The LF diagnostic cut-off value in differentiating mild and moderate to severe inflammation in 105 viral hepatitis patients was 2.915, with a sensitivity of 80.0% and specificity 57.8%. The LF index was not correlated with degrees of liver fibrosis and inflammation in 75 non-viral hepatitis patients. Conclusion: LF index can reflect the degree of liver fibrosis and inflam- mation, the higher the diagnostic sensitivity, the greater the LF index, the more severe liver fibrosis and the degree of inflammation. |
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