| 曹甜甜,张 巍,张 云,王 鑫,刘 洁.强心益气方联合瑞舒伐他汀治疗急性心肌梗死的疗效及对患者血清相关指标的影响[J].现代生物医学进展英文版,2017,17(5):866-869. |
| 强心益气方联合瑞舒伐他汀治疗急性心肌梗死的疗效及对患者血清相关指标的影响 |
| Clinical Efficacy of Qiangxinyiqi Decoction Combined with Rosuvastatin in Treatment of Acute Myocardial Infarction and the Effects on White Blood Count(WBC), NEU, Myoglobin and C-reactive Protein(CRP) Levels |
| Received:August 20, 2016 Revised:September 15, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.05.016 |
| 中文关键词: 强心益气方 瑞舒伐他汀 急性心肌梗死 白细胞计数 中性粒细胞比值 肌红蛋白 C反应蛋白 |
| 英文关键词: Qiangxinyiqi decoction Rosuvastatin Acute myocardial infarction White blood count(WBC) NEU Myoglobin C-reactive protein(CRP) |
| 基金项目:北京市自然科学基金项目(7092089) |
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| 中文摘要: |
| 摘要 目的：探讨强心益气方联合瑞舒伐他汀治疗急性心肌梗死的临床疗效及对患者白细胞计数（WBC）、中性粒细胞比值（NEU）、肌红蛋白及C反应蛋白（CRP）水平的影响。方法：选自2014年6月~2015年12月我院收治的急性心肌梗死患者96例，随机分为观察组与对照组，每组48例。对照组采用瑞舒伐他汀治疗，观察组在对照组基础上给予强心益气方治疗。观察并比较两组患者的治疗疗效以及治疗前后心功能指标、WBC、NEU、肌红蛋白、CRP水平变化，及用药期间不良反应情况。结果：观察组治疗总有效率（89.58%）高于对照组（70.83%）（P<0.05）；与治疗前比较，两组LVEF、SV治疗后明显升高，而LVEDV明显降低（P<0.05）；观察组LVEF、SV治疗后高于对照组，而LVEDV低于对照组（P<0.05）；与治疗前比较，两组WBC、NEU、肌红蛋白、CRP水平治疗后明显降低（P<0.05）；观察组WBC、NEU、肌红蛋白、CRP水平治疗后低于对照组（P<0.05）；两组均未见严重不良反应。结论：强心益气方联合瑞舒伐他汀治疗急性心肌梗死患者疗效显著，可降低WBC、NEU、肌红蛋白、CRP含量，安全可靠，值得研究。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of Qiangxinyiqi decoction combined with rosuvastatin in treatment of acute myocardial infarction and the effects on the levels of white blood count (WBC), NEU, myoglobin and C-reactive protein(CRP). Methods: 96 patients with acute myocardial infarction who were treated in our hospital from June 2014 to December 2015 were selected and randomly divided into the observation group and the control group, with 48 cases in each group. The patients in the control group were treated with rosuvastatin, while the patients in the observation group were treated with Qiangxinyiqi decoction on the basis of the control group. Then the clinical efficacy and the indexes of heart function and the levels of white blood count (WBC), NEU, myoglobin and C-reactive protein(CRP) and the adverse reactions between the two groups were observed and compared. Results: The total effective rate in observation group was 89.58%, which was significantly higher than 70.83% in the control group (P<0.05); Compared with before treatment, the levels of LVEF and SV in the two groups significantly increased after the treatment, while the LVEDV decreased (P<0.05); After treatment, the levels of LVEF and SV in the observation group were significantly higher than those of the control group, while the LVEDV was lower (P<0.05); Compared with before treatment, the levels of white blood count(WBC), NEU, myoglobin and C-reactive protein(CRP) in the t6wo groups decreased after the treatment (P<0.05); After treatment, the levels of the white blood count(WBC), NEU, myoglobin and C-reactive protein(CRP) in the observation group were lower than those of the control group (P<0.05); There were no serious adverse reaction in the two groups. Conclusion: Qiangxinyiqi decoction combined with rosuvastatin in treatment of acute my- ocardial infarction brought has obvious effects which can reduce the levels of white blood count(WBC), NEU, myoglobin and C-reactive protein(CRP), and it is worthy of clinical application. |
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