| 廖 飞,韩吉华,邵佳琳,郑 朝,孟宪志.MicroRNA和自噬参与胆管癌发病机制的研究进展[J].现代生物医学进展英文版,2017,17(4):780-783. |
| MicroRNA和自噬参与胆管癌发病机制的研究进展 |
| Research Progress of microRNA and Autophagy on the Pathogenesis of Cholangiocarcinoma |
| Received:April 09, 2016 Revised:April 30, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.04.047 |
| 中文关键词: MicroRNA 自噬 胆管癌 |
| 英文关键词: MicroRNA Autophagy Cholangiocarcinoma |
| 基金项目:黑龙江省教育厅科学研究基金项目（12541305） |
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| 中文摘要: |
| 摘要：胆管癌是一种高度转移的恶性肿瘤，包括肝内胆管癌和肝外胆管癌，目前手术被认为是唯一的根治方案。胆管癌在全球的发病率和死亡率不断增加，原因很可能与早期胆管癌没有明显的临床表现，确诊时通常已达晚期阶段，及预后差、极易复发的特点有关。与人类胆管癌相关的microRNAs有很多，调节着胆管肿瘤的发生发展。此外，自噬作为细胞内环境的一种调节机制，也调节肿瘤恶变和癌症进展，在不同情况下治疗性干预，促进或抑制自噬将有利于胆管癌患者。现将microRNA和自噬参与胆管癌发生发展作一综述。 |
| 英文摘要: |
| ABSTRACT: Cholangiocarcinoma (CCA), regarded as a highly metastatic cancer, occurs in either intrahepatic or extrahepatic biliary tract. Surgery is considered as the only curative treatment. The incidence and mortality of CCA are increasing worldwide, the reason of which may be that there is no specific clinical manifestation in earlier stage of CCA and it has usually developed into later period when diagnosed. Patients with CCA are also poorly prognosed as well as at a high risk to tumor recurrence. There are a large number of microRNAs associated with CCA in humans, which contribute to the carcinogenesis of biliary tract. In addition, autophagy, as an intracellular control mechanism, modulates the transformation and progression of CCA, too. Therapeutic interventions enhancing or decreasing autophagy, depending on the context, can be beneficial to CCA patients. In this article the literatures about the microRNA and autophagy in the Cholangiocarcinoma are reviewed. |
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