| 张红艳,胡迎新,崔 粲,郑煜凡,卞正阳.甲硝唑药膜联合盐酸米诺环素软膏治疗牙周病的临床疗效分析[J].现代生物医学进展英文版,2017,17(4):746-749. |
| 甲硝唑药膜联合盐酸米诺环素软膏治疗牙周病的临床疗效分析 |
| Clinical Effect of Metronidazole Membrane combined with Minocycline Ointment for Periodontal Disease |
| Received:August 03, 2016 Revised:August 23, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.04.038 |
| 中文关键词: 甲硝唑药膜 盐酸米诺环素软膏 牙周病 |
| 英文关键词: Metronidazole membrane Minocycline ointment Periodontal disease |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：研究甲硝唑药膜联合盐酸米诺环素软膏治疗牙周病的临床疗效。方法：选择2014年1月～2016年1月在我院进行诊治的牙周病患者80例，随机分为两组。观察组采用甲硝唑药膜联合盐酸米诺环素软膏治疗治疗，对照组采用甲硝唑药膜治疗。观察并比较两组的疗效，牙周附着指数、牙菌斑指数、牙龈指数、牙齿松动度和白介素-6、白介素-8和肿瘤坏死因子的水平。结果：治疗4周后，观察组的治疗有效率为95.0 %，明显高于对照组的90.0 % (P<0.05)；治疗后两组的牙周附着指数、牙菌斑指数、牙龈指数和牙齿松动度均较治疗前明显降低(P<0.05)，且观察组的降低程度明显优于对照组(P<0.05)；治疗后两组的肿瘤坏死因子、白介素-6和白介素-8均较治疗前明显降低(P<0.05)，且观察组的降低程度明显优于对照组(P<0.05)；两组间丘疹、恶心、胃肠道反应和失眠的发生情况相比无明显差异(P>0.05)；观察组的复发率为2.5 %，明显低于对照组的7.5 %(P<0.05)。结论：甲硝唑药膜联合盐酸米诺环素软膏能增强对牙周病各种致病菌的抑制作用，提高临床疗效，改善牙周状况和炎症状态，不良反应少，且复发率低，值得推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect of metronidazole membrane combined with minocycline ointment on periodontal disease. Methods: 80 cases of patients with periodontal disease in our hospital from January 2014 to January 2016 were select and divided into observation group and control group. The patients in the observation group were treated with metronidazole membrane combined with minocycline ointment, and the patients in the control group were adopted metronidazole membrane. The curative effect, periodontal attachment index, plaque index, gingival index, tooth mobility degree and the levels of serum IL-2, IL-6, IL-8 and TNF were compared between the two groups. Results: After 4 weeks, The curative effect of the observation group(95.0%) was significantly higher than that of the control group(90.0%)(P<0.05); the periodontal attachment index, plaque index, gingival indexand tooth mobility degree and the levels of serum IL-2, IL-6, IL-8 and TNF in two groups were all were significantly decreased(P<0.05), and the reduce degree of observation group was more obviously than that of the control group(P<0.05); no difference was found between the two groups as to pimples, nausea and gastrointestinal reaction and insomnia(P>0.05); the recurrence rate of the observation group(2.5%)was significantly lower than that of the control group(7.5%). Conclusion: Metronidazole membrane combined with minocycline ointment can enhance inhibition of periodontal pathogens, and improve the clinical effect, the periodontal condition and state of inflammation, and has less adverse reactions, low recurrence rate, worthy of application. |
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