| 何 丹,涂小琼,李 燕,贾德昭,揭海霞.经鼻间歇正压通气联合猪肺磷脂注射液治疗新生儿呼吸窘迫综合征的临床疗效[J].现代生物医学进展英文版,2017,17(4):705-708. |
| 经鼻间歇正压通气联合猪肺磷脂注射液治疗新生儿呼吸窘迫综合征的临床疗效 |
| Clinical Efficacy and Safety of Nasal Intermittent Positive Pressure Ventilation combined with Poractant Alfa Injection in the Treatment of Neonatal Respiratory Distress Syndrome |
| Received:September 12, 2016 Revised:September 29, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.04.027 |
| 中文关键词: 经鼻间歇正压通气 猪肺磷脂注射液 呼吸窘迫综合征 临床疗效 |
| 英文关键词: Nasal intermittent positive pressure ventilation Poractant alfa injection Respiratory distress syndrome Clinical efficacy |
| 基金项目:湖北省卫生厅科研基金项目(Y02065) |
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| 中文摘要: |
| 摘要 目的：探讨经鼻间歇正压通气联合猪肺磷脂注射液治疗新生儿呼吸窘迫综合征临床疗效及安全性的影响。方法：前瞻性研究于我院进行治疗的呼吸窘迫综合症患儿60例，根据电脑生成的随机数字表将所有患儿随机分为实验组与对照组，每组各30例，对照组患儿使用经鼻间歇正压通气进行治疗，实验组患儿在对照组的基础上联合猪肺磷脂注射液进行治疗。治疗结束后比较两组患儿动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）、氧合指数及血样饱和度（SaO2）水平的变化，统计并记录两组患儿并发症的发病情况，并对两组患儿的临床疗效进行评价。结果：与治疗前相比，两组患儿PaCO2水平均降低，PaO2、SaO2水平及氧合指数均升高（P＜0.05）；与对照组相比，实验组患儿PaCO2水平较低，PaO2、SaO2水平及氧合指数较高（P＜0.05）；且与对照组相比，实验组的并发症发病率较低，临床总有效率较高（P＜0.05）。结论：经鼻间歇正压通气联合猪肺磷脂注射液治疗新生儿呼吸窘迫综合征安全有效，值得在临床上推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy and safety of nasal intermittent positive pressure ventilation combined with poractant alfa injection in the treatment of neonatal respiratory distress syndrome. Methods: 60 children with respiratory distress syndrome who were treated in our hospital were selected and randomly divided into experiment group and control group with 30 cases in each group. The patients in the control group were treated with nasal intermittent positive pressure ventilation treatment, and the patients in the experiment group were treated with poractant alfa injection on the basis of the control group. Then the levels of the arterial blood oxygen partial pressure(PaO2), arterial blood CO2 partial pressure (PaCO2), oxygenation index and blood sample saturation (SaO2) and the clinical efficacy and the incidence of the complications in the two groups were observed and compared before and after the treatment. Results: Compared with before treatment, the levels of PaCO2 in the two groups decreased after treatment, while the levels of PaO2 and SaO2 and oxygenation index increased (P<0.05); Compared with the control group, the level of PaCO2 in the experiment group was lower, while the levels of PaO2 and SaO2 and the oxygenation index were higher (P<0.05); Compared with the control group, the incidence of complications in the experiment was lower, and the clinical total effective rate was higher (P < 0.05). Conclusion: Nasal intermittent positive pressure ventilation combine with poractant alfa injection in the treatment of neonatal respiratory distress syndrome is safe and effective, which is worth of clinical application. |
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