| 蒋 宜,裴文楠,唐渝平,李宝善,李婷婷,马厚勋.小剂量甲状腺素联合厄贝沙坦氢氯噻嗪治疗老年重症心力衰竭的效果观察[J].现代生物医学进展英文版,2017,17(4):676-679. |
| 小剂量甲状腺素联合厄贝沙坦氢氯噻嗪治疗老年重症心力衰竭的效果观察 |
| Efficacy of Small Dose Thyroxine Combined with Irbesartan and Hydrochlorothiazide in the Treatment of Senile Severe Heart Failure |
| Received:September 12, 2016 Revised:September 30, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.04.019 |
| 中文关键词: 重症心力衰竭 厄贝沙坦氢氯噻嗪 甲状腺素 老年患者 |
| 英文关键词: Severe heart failure Irbesartan and hydrochlorothiazide Thyroxine Elderly patients |
| 基金项目:重庆市自然科学基金项目(7082032) |
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| 中文摘要: |
| 摘要 目的：探究使用小剂量甲状腺素联合厄贝沙坦氢氯噻嗪治疗老年重症心力衰竭（CHF）中的治疗效果。方法：将37例本院老年CHF患者随机分做实验组（19例）及对照组（18例）。对照组予厄贝沙坦氢氯噻嗪片及美托洛尔治疗；实验组予厄贝沙坦氢氯噻嗪片、美托洛尔及左旋甲状腺素钠片治疗。对比治疗前后两组患者心力衰竭症状、心功能及甲状腺素水平的变化。结果：实验组总有效率(94.7%)高于对照组(77.8%)，差异具有统计学意义（P<0.05）；两组患者左心室射血分数（LVEF）水平及胱抑素C水平增加，纽约心脏病协会分级（NYHA）及B型脑钠肽水平均降低（P<0.05）；与对照组相比，实验组LVEF及胱抑素C水平较高，NYHA分级及B型脑钠肽水平较低，差异存在统计学意义（P<0.05）；两组血清三碘甲状腺原氨酸（T3）、血清甲状腺素（T4）水平均升高（P<0.05），与对照组相比，实验组血清T3、T4水平较高，差异具有统计学意义（P<0.05）。结论：小剂量甲状腺素联合厄贝沙坦氢氯噻嗪治疗老年CHF的效果显著，可以明显改善心力衰竭症状、提高LVEF水平，降低NYHA分级及血清中B型脑钠肽水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of small dose thyroxine combined with irbesartan and hydrochlorothiazide in the treatment of elderly patients with severe heart failure (CHF). Methods: 37 elderly patients with CHF who were treated in our hospital were selected and randomly divided into experiment group (19 cases) and control group (18 cases). The patients in the control group were treated with irbesartan and hydrochlorothiazide tablets and metoprolol, and the patients in the experiment group were treated with irbesartan, hydrochlorothiazide, metoprolol and levothyroxine sodium tablets. Then the heart failure symptoms and heart function and thyroxine levels of the two groups were observed and compared before and after treatment. Results: The total effective rate of the experiment group was 94.7% which was higher than 77.8% of the control group, and the difference was statistically significant (P<0.05); Compared with before treatment, the left ventricular ejection fraction (LVEF) and cystatin C levels of the two groups increased after treatment, while the New York heart association (NYHA) classification and b-type brain natriuretic peptide levels decreased (P<0.05); Compared with the control group, the levels of the LVEF and cystatin C in the experiment group were higher, and the NYHA classification and b-type brain natriuretic peptide levels were lower, and the differences were statistically significant (P<0.05); Compared with before treatment, the serum triiodothyronine (T3) and serum thyroxine (T4) levels of the two groups increased after treatment (P < 0.05); Compared with the control group, the serum T3 and T4 levels of the experiment group were higher, and the differences were statistically significant (P<0.05). Conclusion: Small dose thyroxine combine with irbesartan and hydrochlorothiazide in the treatment of elderly patients with CHF can obviously improve the symptoms of heart failure, increase the level of LVEF, decrease the NYHA classification and serum b-type brain natriuretic peptide levels, and improve the levels of serum T3 and T4. |
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