| 张效林,梁振洋,孙 莹,刘滕飞,蔡文芝,闫承慧.趋化因子CX3CL1与冠心病合并2 型糖尿病发病的相关关系[J].现代生物医学进展英文版,2017,17(4):645-648. |
| 趋化因子CX3CL1与冠心病合并2 型糖尿病发病的相关关系 |
| The Association between the Chemokine CX3CL1 and Coronary Artery Disease in Type 2 Diabetes Mellitus |
| Received:April 28, 2016 Revised:May 22, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.04.011 |
| 中文关键词: 冠心病 2 型糖尿病 CX3CL1基因 单核苷酸多态性 基因型 |
| 英文关键词: Coronary Artery Disease Type 2 Diabetes Mellitus CX3CL1 Single nucleotide polymorphism Genotype |
| 基金项目:国家自然科学基金项目（81100135） |
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| 中文摘要: |
| 摘要 目的：探讨趋化因子CX3CL1与冠心病合并2 型糖尿病发病的相关关系。方法：采用病例-对照的研究方法，收集冠心病合并2型糖尿病患者400例，收集对照组400例，利用免疫组化检测冠心病合并2 型糖尿病患者颈外动脉旋切术后斑块组织中CX3CL1表达水平，分别检测上述2组不同人群血清中的CX3CL1表达水平，同时采用直接测序方法检测CX3CL1基因rs170364位点基因型及等位基因的分布频率在对照组和冠心病合并2 型糖尿病人群的分布差异。结果：冠心病合并2 型糖尿病患者颈外动脉斑块组织中CX3CL1表达明显增高，冠心病合并2 型糖尿病患者血清中CX3CL1的表达水平明显高于对照人群中CX3CL1的表达。CX3CL1基因rs170364单核苷酸多态位点的三种基因型分布频率（GG型，GT型和TT型）在冠心病合并2 型糖尿病患者的分布频率为42.7%，40.0%和17.2%，在对照组分布频率为50.2%，39.6%和10.2%，CX3CL1基因rs170364位点T等位基因是冠心病合并2 型糖尿病发病的一个独立危险因素(P＜0.05)。Logistic回归校正性别、年龄、体重指数、吸烟、高血压、高脂血症等冠心病合并2 型糖尿病的易患因素后，CX3CL1基因rs170364 T等位基因仍是冠心病合并2型糖尿病发病的一个独立的危险因素。结论：CX3CL1在冠心病合并2 型糖尿病的患者血清和颈外动脉动脉血管组织中表达明显增高，CX3CL1基因rs170364 T等位基因可能是冠心病合并2 型糖尿病患者发病的独立危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: CX3CL1 played an important role in atherosclerosis recently. We investigated the association between the chemokine CX3CL1 with coronary artery disease in type 2 diabetes mellitus. Methods: CX3CL1 expression in carotid artery specimens was analysed by immunohistochemistry. The study was conducted in 400 coronary artery disease in type 2 diabetes mellitus and 400 control subjects in a case-control study.CX3CL1 gene rs170364 variant was detected by the directing sequencing technology. Results: CX3CL1 expressions were increased markedly in carotid artery plaque than in normal carotid artery. CX3CL1 gene rs170364 genotype (GG，GT and TT) frequency in coronary artery disease in type 2 diabetes mellitus is 42.7%, 40.0% and 17.2%, and 50.2%, 39.6% and 10.2% in the control group. CX3CL1 gene rs170364 variant is a genetic risk factor for coronary artery disease in type 2 diabetes mellitus (P＜0.05). Logistic regression analysis with adjustments for other risk factors showed that the CX3CL1 gene rs170364 T allele significantly increases the risk of coronary artery disease in type 2 diabetes mellitus compared with the control subjects (P＜0.05). Conclusion: Our study shows that the CX3CL1 expression increased in the carotid plaques and serum of the coronary artery disease in type 2 diabetes mellitus.CX3CL1 gene rs170364 variant may be considered a genetic risk factor for coronary artery disease in type 2 diabetes mellitus. |
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