| 彭羽瑶 张浩然 易明玉 吴婷 刘超 肖乐 李昌琪.ApoE与beta淀粉样蛋白在阿尔茨海默病中相互作用的研究进展[J].现代生物医学进展英文版,2017,17(2):396-400. |
| ApoE与beta淀粉样蛋白在阿尔茨海默病中相互作用的研究进展 |
| The Recent Advance in Interactions between Apolipoprotein E andAmyloid-beta in Alzheimer's Disease |
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| DOI： |
| 中文关键词: 阿尔茨海默症 beta淀粉样蛋白 载脂蛋白E A-beta 沉积假说 |
| 英文关键词: Alzheimer's disease Amyloid-beta Apolipoprotein E Amyloid hypothesis |
| 基金项目:国家自然科学基金项目（31371212）；湖南省科技厅社发处项目（2015SK2029）；中南大学大学生自由探索项目（YC2016709） |
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| 中文摘要: |
| 阿尔茨海默病( Alzheimer's disease，AD)是一种中枢神经系统神经退行性疾病，至今尚未明确其发病机制，但基于其典型的
病理特征之一是beta淀粉样蛋白(amyloid-beta, Abeta)聚集，A茁沉积假说一直都是研究的重点。近年来，载脂蛋白E(apolipoprotein E,
APOE)对Abeta代谢清除的影响备受关注。研究表明，APOE着4 等位基因是散发性AD 的危险因素，且APOE 对Abeta具有很高的亲和
力，不同亚型的APOE 对Abeta的代谢有不同的影响，这为对AD的认识、防止及治疗提供了新的研究方向。 |
| 英文摘要: |
| Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system. Its pathogenesis is still
incompletely understood. The accumulation of amyloid-beta (Abeta) is one of the typical pathologic symptoms, and the "amyloid
hypothesis" has dominated Alzheimer research for a long time. Recently, the effect of apolipoprotein E (APOE) in Abeta metabolism
attracts extensive concern. It suggests that ε4 allele is a risk factor in sporadic Alzheimer disease. Apolipoprotein E has a high affinity
with A-beta, while different isoforms of apolipoprotein E have different influences on A-beta metabolism. These results provide a new way for
the identification, prevention and therapy of AD. |
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