| 李斌 李玲玲 冀会方 林宏英 张小华 王灵芝.生物肽降压作用机制及定量构效关系的研究[J].现代生物医学进展英文版,2017,17(2):374-377. |
| 生物肽降压作用机制及定量构效关系的研究 |
| Research on the Antihypertensive Mechanisms and QuantitativeStructure-activity Relationship of Bioactive Peptides |
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| DOI： |
| 中文关键词: 生物肽 血管紧张素转化酶 高血压 定量构效关系 |
| 英文关键词: Bioactive peptides Angiotensin converting enzyme Hypertension Quantitative structure-activity relationship |
| 基金项目:国家自然科学基金青年科学基金项目(81102750)；国家自然基金重点项目(81430094)；北京中医药大学课题(2015-JYB-JSMS026) |
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| 中文摘要: |
| 高血压是心脑血管疾病的首要危险因素，严重威胁着人类的生命健康。生物肽能有效预防和治疗高血压，并且具有安全可
靠、作用多靶点等特点。大量的研究表明生物肽存在多种降压作用机制，深入研究降压机制可为中药治疗高血压提供新思路。本
文综述了近年来生物肽潜在的降压机制，并探索其定量构效关系，旨在为中药药效组分的研究以及相关药物设计和筛选提供理
论指导。 |
| 英文摘要: |
| Hypertension is the most dangerous factor that causes cardiovascular and cerebrovascular diseases, and a great threat
to human's life and health. Bioactive peptides, which can effectively prevent or treat hypertension, have the characteristics of high safety
and reliability, multiple action targets, etc. A lot of researches have shown that bioactive peptides have various mechanisms that can
explain their anti-hypertensive effects. Thorough studies on bioactive peptides can further illustrate the antihypertensive mechanisms of
herbs. This paper reviewed the potential anti-hypertensive mechanismof bioactive peptides and explored its quantitative structure-activity
relationship, which could provide guidance for the studies of the effective components in traditional Chinese medicines and the related
drug design and drug screening. |
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