| Objective:To study the pathogenic bacteria distribution and risk factors of nosocomial infections in advanced lung
cancer patients underwent chemotherapy,so as to provide the reference for clinical prevention and reduction of nosocomial infections.Methods:A total of 235 patients with advanced lung cancer who were underwent chemotherapy in our hospital from September 2012 to
September 2015 were selected for the research, the clinical data were investigated and analyzed,and the bacteria identification and drug
sensitivity test were carried out on nasal swab, sputumspecimen and ascites, etc. The risk factors of nosocomial infection in patients with
advanced lung cancer underwent chemotherapy were analyzed.Results:In those 235 patients, 65 patients occurred nosocomial infection,
the infection rate was 27.66%, 75 strains of pathogenic bacteria were detected, including 41 strains of gram negative bacteria, accounting
for 54.67%, 26 strains of gram positive bacteria, accounting for 34.67%, and 8 strains of fungi, accounting for 10.67%. Drug resistance
rate of Klebsiella pneumoniae to ampicillin was highest to 80.00%, and the sensitive rate to vancomycin was highest to 100.00%; Drug
resistance rate of Staphylococcus aureus to penicillin was highest to 94.74%, and the sensitive rate to linezolid was highest to 100.00%.
Logistic regression analysis showed that, the mainly risk factors of nosocomial infection in patients with advanced lung cancer underwent
chemotherapy were: age≥ 60 years old and clinical stage IV, radiotherapy, anemia, using antibiotics and hospitalization time≥ 15 days.Conclusion:The main pathogenic bacterias causing nosocomial infection in patients with advanced lung cancer underwent chemotherapy
were and , and age ≥ 60 years old and clinical stage IV, radiotherapy,anemia,using
antibiotics and hospitalization time≥ 15 days were its risk factors, which should pay attention in clinical practice. |
