| 王艳 史玉红 李圣 徐靖华 李建林.氯吡格雷联合阿司匹林对冠心病心绞痛患者血清hs-CRP, TNF-alpha 及IL-6 水平的影响[J].现代生物医学进展英文版,2017,17(2):327-330. |
| 氯吡格雷联合阿司匹林对冠心病心绞痛患者血清hs-CRP, TNF-alpha 及IL-6 水平的影响 |
| Effects of Clopidogrel and Aspirin on the SerumLevels of hs-CRP, TNF-alkpha and IL-6 in Patients with Coronary Heart Disease and Angina Pectoris |
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| DOI： |
| 中文关键词: 冠心病 心绞痛 炎症因子 氯吡格雷 阿司匹林 |
| 英文关键词: Coronary heart disease Angina pectoris Inflammatory factors Clopidogrel Aspirin |
| 基金项目:辽宁省科技厅计划项目(2013226012) |
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| 中文摘要: |
| 目的：探讨氯吡格雷与阿司匹林对冠心病心绞痛患者血清炎症因子水平的影响及其临床疗效。方法：选择2014 年3月-2016
年3 月在我院确诊为冠心病心绞痛患者69 例作为研究对象，根据治疗方法不同，将患者随机分成研究组（39 例）和对照组（30
例）。对照组患者采用阿司匹林治疗，研究组患者在此基础上联合使用氯吡格雷治疗。观察并比较两组患者治疗前后血清高敏C-
反应蛋白(high-sensitivity C-reactive protein, hs-CRP)、肿瘤坏死因子-alpha（tumor necrosis factor-alpha, TNF-alpha）及白细胞介素-6
(interleukin-6, IL-6)水平的变化情况，以及临床疗效。结果：治疗前两组患者血清hs-CRP，IL-6 及TNF-alpha水平比较，差异无统计学
意义（P>0.05）；治疗后两组患者血清hs-CRP，IL-6 及TNF-alpha水平均低于治疗前，且研究组低于对照组，差异具有统计学意义（P<0.
05）。研究组患者临床总有效率（94.7%）高于对照组（88.9%），差异具有统计学意义（P<0.05）。结论：氯吡格雷联合阿司匹林治疗冠
心病心绞痛的临床效果显著，能够降低患者血清hs-CRP，IL-6 及TNF-alpha炎症因子水平，值得临床推广应用。 |
| 英文摘要: |
| Objective:To investigate the effect of clopidogrel and aspirin on serum levels of inflammatory factors in patients with
coronary heart disease and angina pectoris.Methods:69 cases with angina pectoris and coronary heart disease who were diagnosed in our
hospital from March 2014 to March 2016 were selected as the research objects, and according to the different treatment methods, the
patients were randomly divided into the study group (39 cases) and the control group (30 cases). The patients in the control group were
treated with aspirin, and the patients in the study group were treated with clopidogrel on the basis of the control group. Then the serum
levels of high sensitive C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-alpha) and leukocyte mediated IL-6 (IL-6) in patients
between the two groups before and after treatment were observed and compared.Results:Before treatment, there was no statistically
significant difference about the serum levels of hs-CRP, IL-6 and TNF-alpha between the two groups (P > 0.05); After treatment, the serum
levels of hs-CRP, IL-6 and TNF-alpha in the two groups were lower than before, and the study group was lower than that of the control
group, and the differences were statistically significant (P<0.05). The total effective rate in the study group was 94.7%, which was higher
than 81.9% in the control group, and the difference was statistically significant (P<0.05).Conclusion:The clinical effect of clopidogrel
combined with aspirin in the treatment of angina pectoris and coronary heart disease is significant, which can reduce the serum levels of
hs-CRP, IL-6 and TNF- alpha and it is worthy of clinical application. |
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